σ1 Receptor antagonist 4
σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters.
For research use only. We do not sell to patients.
- CAS No.: 362512-81-0
- Formula: C19H20FNO
- Molecular Weight:297.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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σ1R 10 nM (Ki) |
σ2 370 nM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss-Webster mice (Hsd:ND4, aged 2-3 month) injected with Cocaine[1]
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Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg
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Administration:i.p.; once
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Result:Attenuated the stimulatory locomotor effect of 20 mg/kg Cocaine.
Chemical Information
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CAS No. 362512-81-0
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Molecular Weight 297.37
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Formula C19H20FNO
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SMILES
OC12[C@H]3[C@@H]4C(C5C2C6[C@@H]3[C@H]4C5C6)N1CCC7=CC(F)=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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