γ-Fagarine
Based on 1 Customer Validation
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer.
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 524-15-2
- Formula: C13H11NO3
- Molecular Weight:229.23
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
IC50: 20.4 μg/mL (HCV)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>160 μM
Compound: 16
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Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
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[PMID: 22093759] |
| Neutrophil | IC50 |
>100 μM
Compound: 8
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Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
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[PMID: 17822293] |
| Neutrophil | IC50 |
>50 μM
Compound: 16
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Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
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[PMID: 18211005] |
| Neutrophil | IC50 |
31.31 μM
Compound: 16
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Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
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[PMID: 18211005] |
| Neutrophil | IC50 |
7.17 μg/mL
Compound: Gamma-fagarine
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Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
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[PMID: 19128011] |
Chemical Information
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CAS No. 524-15-2
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Appearance Solid
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Molecular Weight 229.23
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Formula C13H11NO3
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Color White to off-white
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SMILES
COC1=C2N=C(OC=C3)C3=C(OC)C2=CC=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Tutik Sri Wahyuni, et al. Inhibition of Hepatitis C Virus Replication by Chalepin and Pseudane IX Isolated From Ruta Angustifolia Leaves. Fitoterapia. 2014 Dec;99:276-83. [Content Brief]
[2]. O Schimmer, et al. The SCE-inducing Potency of the Furoquinoline Alkaloid, Gamma-Fagarine, and a Gamma-Fagarine-Containing Tincture From Rutae Herba, in Cultured Human Lymphocytes. Mutagenesis. 1989 Nov;4(6):467-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-Fagarine Related Classifications
HY-N3918 Related Classifications
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