1-(1-Naphthyl)piperazine hydrochloride
Based on 1 Customer Validation
1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis.
For research use only. We do not sell to patients.
- Purity: 99.22%
- CAS No.: 104113-71-5
- Formula: C14H17ClN2
- Molecular Weight:248.75
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1A Receptor |
5-HT2A Receptor |
1-1-Naphthylpiperazine hydrochloride (50-300 μM) suppresses the melanoma cells MNT-1 with an IC50 is 163.6 μM, by inducing the cell cycle arrest at S-phase, cell apoptosis and ROS generation[1].
1-1-Naphthylpiperazine hydrochloride (0-200 μM) regulates the expressions of related genes, which are associated with the UV-induced immunosuppression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:UVB-radiation exposed C57BL/6 mice and XPA-/- mice[2]
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Dosage:1 μM
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Administration:i.p., single dose
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Result:Accelerated the repair of UV-induced photoproducts with presence of NER.
Chemical Information
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CAS No. 104113-71-5
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Appearance Solid
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Molecular Weight 248.75
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Formula C14H17ClN2
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Color Gray to brown
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SMILES
C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl
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Synonyms
1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 300 mg/mL (1206.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (20.10 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78. [Content Brief]
[2]. Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130(5):1428-37. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 4.0201 mL | 20.1005 mL | 40.2010 mL | 100.5025 mL |
| 5 mM | 0.8040 mL | 4.0201 mL | 8.0402 mL | 20.1005 mL | |
| 10 mM | 0.4020 mL | 2.0101 mL | 4.0201 mL | 10.0503 mL | |
| 15 mM | 0.2680 mL | 1.3400 mL | 2.6801 mL | 6.7002 mL | |
| 20 mM | 0.2010 mL | 1.0050 mL | 2.0101 mL | 5.0251 mL | |
| DMSO | 25 mM | 0.1608 mL | 0.8040 mL | 1.6080 mL | 4.0201 mL |
| 30 mM | 0.1340 mL | 0.6700 mL | 1.3400 mL | 3.3501 mL | |
| 40 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5126 mL | |
| 50 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 60 mM | 0.0670 mL | 0.3350 mL | 0.6700 mL | 1.6750 mL | |
| 80 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 100 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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