1-(1-Naphthyl)piperazine hydrochloride  (Synonyms: 1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride)

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis^[1].

1-1-Naphthylpiperazine hydrochloride (50-300 μM) suppresses the melanoma cells MNT-1 with an IC₅₀ is 163.6 μM, by inducing the cell cycle arrest at S-phase, cell apoptosis and ROS generation^[1].
1-1-Naphthylpiperazine hydrochloride (0-200 μM) regulates the expressions of related genes, which are associated with the UV-induced immunosuppression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-1-Naphthylpiperazine hydrochloride (1 μM, i.p., single dose) promotes the DNA repair induced by UV radiation through the mechanism involving nucleotid excision repair(NER), which prevents the immune suppression and interferes the photocarcinogenesis in UVB exposed C57BL/6 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

248.75

C₁₄H₁₇ClN₂

104113-71-5

C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78.  [Content Brief]

  [2]. Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130(5):1428-37.  [Content Brief]