2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. 5-HT Receptor Apoptosis
  4. 1-(1-Naphthyl)piperazine hydrochloride

1-(1-Naphthyl)piperazine hydrochloride  (Synonyms: 1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride)

Cat. No.: HY-112538
Handling Instructions Technical Support

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis.

For research use only. We do not sell to patients.

1-(1-Naphthyl)piperazine hydrochloride

1-(1-Naphthyl)piperazine hydrochloride Chemical Structure

CAS No. : 104113-71-5

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg Get quote
50 mg Get quote
100 mg Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of 1-(1-Naphthyl)piperazine hydrochloride:

1-(1-Naphthyl)piperazine hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].

IC50 & Target

5-HT1A Receptor

 

5-HT2A Receptor

 

In Vitro

1-1-Naphthylpiperazine hydrochloride (50-300 μM) suppresses the melanoma cells MNT-1 with an IC50 is 163.6 μM, by inducing the cell cycle arrest at S-phase, cell apoptosis and ROS generation[1].
1-1-Naphthylpiperazine hydrochloride (0-200 μM) regulates the expressions of related genes, which are associated with the UV-induced immunosuppression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-(1-Naphthyl)piperazine hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: MNT-1
Concentration: 50-300 μM
Incubation Time: 3-24 h
Result: Inhibited cell viability

RT-PCR[1]

Cell Line: MNT-1
Concentration: 0-150 μM
Incubation Time: 24 h
Result: Downregulated levels of PAK1, upregulated levels of PTGS2 and IL12A.
In Vivo

1-1-Naphthylpiperazine hydrochloride (1 μM, i.p., single dose) promotes the DNA repair induced by UV radiation through the mechanism involving nucleotid excision repair(NER), which prevents the immune suppression and interferes the photocarcinogenesis in UVB exposed C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UVB-radiation exposed C57BL/6 mice and XPA-/- mice[2]
Dosage: 1 μM
Administration: i.p., single dose
Result: Accelerated the repair of UV-induced photoproducts with presence of NER.
Molecular Weight

248.75

Formula

C14H17ClN2
CAS No.
Appearance

Solid

SMILES

C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (1206.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0201 mL 20.1005 mL 40.2010 mL
5 mM 0.8040 mL 4.0201 mL 8.0402 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0201 mL 20.1005 mL 40.2010 mL 100.5025 mL
5 mM 0.8040 mL 4.0201 mL 8.0402 mL 20.1005 mL
10 mM 0.4020 mL 2.0101 mL 4.0201 mL 10.0503 mL
15 mM 0.2680 mL 1.3400 mL 2.6801 mL 6.7002 mL
20 mM 0.2010 mL 1.0050 mL 2.0101 mL 5.0251 mL
25 mM 0.1608 mL 0.8040 mL 1.6080 mL 4.0201 mL
30 mM 0.1340 mL 0.6700 mL 1.3400 mL 3.3501 mL
40 mM 0.1005 mL 0.5025 mL 1.0050 mL 2.5126 mL
50 mM 0.0804 mL 0.4020 mL 0.8040 mL 2.0101 mL
60 mM 0.0670 mL 0.3350 mL 0.6700 mL 1.6750 mL
80 mM 0.0503 mL 0.2513 mL 0.5025 mL 1.2563 mL
100 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0050 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

1-(1-Naphthyl)piperazine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-(1-Naphthyl)piperazine104113-71-51-NP1-Naphthylpiperazine5-HT ReceptorApoptosisSerotonin Receptor5-hydroxytryptamine ReceptorSK-MEL-28MNT-1C57BL/6 mouseXPA-/- mouseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
1-(1-Naphthyl)piperazine hydrochloride
Cat. No.:
HY-112538
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.