2. PROTAC
  3. PROTAC Linkers
  4. 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 

Cat. No.: HY-W096093 Purity: ≥97.0%
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2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Chemical Structure

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Chemical Structure

CAS No. : 1035373-85-3

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100 mg USD 60 In-stock
250 mg USD 105 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride:

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Related Antibodies

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Description

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Related Antibodies
Molecular Weight

260.20

Formula

C10H23Cl2NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCOCCOCCCCCCCl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (160.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8432 mL 19.2160 mL 38.4320 mL
5 mM 0.7686 mL 3.8432 mL 7.6864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8432 mL 19.2160 mL 38.4320 mL 96.0799 mL
5 mM 0.7686 mL 3.8432 mL 7.6864 mL 19.2160 mL
10 mM 0.3843 mL 1.9216 mL 3.8432 mL 9.6080 mL
15 mM 0.2562 mL 1.2811 mL 2.5621 mL 6.4053 mL
20 mM 0.1922 mL 0.9608 mL 1.9216 mL 4.8040 mL
25 mM 0.1537 mL 0.7686 mL 1.5373 mL 3.8432 mL
30 mM 0.1281 mL 0.6405 mL 1.2811 mL 3.2027 mL
40 mM 0.0961 mL 0.4804 mL 0.9608 mL 2.4020 mL
50 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9216 mL
60 mM 0.0641 mL 0.3203 mL 0.6405 mL 1.6013 mL
80 mM 0.0480 mL 0.2402 mL 0.4804 mL 1.2010 mL
100 mM 0.0384 mL 0.1922 mL 0.3843 mL 0.9608 mL
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2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine1035373-85-3PROTAC LinkersInhibitorinhibitorinhibit

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