3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione

Cat. No.: HY-W888970 Purity: 98.55%: Data Sheet
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3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

For research use only. We do not sell to patients.

3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione Chemical Structure

CAS No. : 2924092-66-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

Biological Activity
Purity & Documentation
References
Customer Review

Description

3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.10

Formula

C₁₁H₉BrFNO₂

CAS No.

2924092-66-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(=O)C(C2=CC=C(Br)C=C2F)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (174.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4953 mL	17.4764 mL	34.9528 mL
5 mM	0.6991 mL	3.4953 mL	6.9906 mL
10 mM	0.3495 mL	1.7476 mL	3.4953 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.55%

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Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (122 KB) RP-HPLC (237 KB) LCMS (337 KB)

Handling Instructions (2659 KB)

References

[1]. Miletić N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4953 mL	17.4764 mL	34.9528 mL	87.3820 mL
	5 mM	0.6991 mL	3.4953 mL	6.9906 mL	17.4764 mL
	10 mM	0.3495 mL	1.7476 mL	3.4953 mL	8.7382 mL
	15 mM	0.2330 mL	1.1651 mL	2.3302 mL	5.8255 mL
	20 mM	0.1748 mL	0.8738 mL	1.7476 mL	4.3691 mL
	25 mM	0.1398 mL	0.6991 mL	1.3981 mL	3.4953 mL
	30 mM	0.1165 mL	0.5825 mL	1.1651 mL	2.9127 mL
	40 mM	0.0874 mL	0.4369 mL	0.8738 mL	2.1846 mL
	50 mM	0.0699 mL	0.3495 mL	0.6991 mL	1.7476 mL
	60 mM	0.0583 mL	0.2913 mL	0.5825 mL	1.4564 mL
	80 mM	0.0437 mL	0.2185 mL	0.4369 mL	1.0923 mL
	100 mM	0.0350 mL	0.1748 mL	0.3495 mL	0.8738 mL