5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
Based on 1 Customer Validation
5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a 2'-O-methyluridine derivative bearing a 5'-O-(4,4'-dimethoxytrityl) protecting group.5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine serves as a starting material for synthesis of a conformationally rigid cyclic uridylic acid derivative.
For research use only. We do not sell to patients.
- Purity: 96.46%
- CAS No.: 103285-22-9
- Formula: C31H32N2O8
- Molecular Weight:560.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5′-O-(4,4′-Dimethoxytrityl)-2′-O-methyluridine (4) (8 h; 30 min) undergoes 3′-O-acetylation followed by deprotection of the 5′-O-dimethoxytrityl group to form 3′-O-acetyl-2′-O-methyluridine (5) with an 86% yield[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103285-22-9
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Appearance Solid
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Molecular Weight 560.59
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Formula C31H32N2O8
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Color Light yellow to yellow
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SMILES
O[C@H]1[C@@H](OC)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (178.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7838 mL | 8.9192 mL | 17.8383 mL | 44.5959 mL |
| 5 mM | 0.3568 mL | 1.7838 mL | 3.5677 mL | 8.9192 mL | |
| 10 mM | 0.1784 mL | 0.8919 mL | 1.7838 mL | 4.4596 mL | |
| 15 mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.9731 mL | |
| 20 mM | 0.0892 mL | 0.4460 mL | 0.8919 mL | 2.2298 mL | |
| 25 mM | 0.0714 mL | 0.3568 mL | 0.7135 mL | 1.7838 mL | |
| 30 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4865 mL | |
| 40 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1149 mL | |
| 50 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8919 mL | |
| 60 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL | |
| 80 mM | 0.0223 mL | 0.1115 mL | 0.2230 mL | 0.5574 mL | |
| 100 mM | 0.0178 mL | 0.0892 mL | 0.1784 mL | 0.4460 mL |
5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine Related Classifications
HY-W025438 Related Classifications
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- 5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine
- 103285-22-9
- Nucleoside Antimetabolite/Analog
- Drug Intermediate
- 3'-O-acetyl-2'-O-methyluridine
- 5'-O-dimethoxytrityl group
- 3'-O-acetylation
- 3'-O-acetyl-5-iodo-2'-O-methyluridine
- 5'-O-(4,4'-dimethoxytrityl) protecting group
- 3'-O-acetyl-5-(2-hydroxypropynyl)-2'-O-methyluridine
- Sonogashira coupling reaction
- conformationally rigid cyclic uridylic acid derivative
- 2'-O-methyluridine
- iodination
- Inhibitor
- inhibitor
- inhibit