9,10-Anthracenediyl-bis(methylene)dimalonic acid (Synonyms: ABMDMA)

Name: 9,10-Anthracenediyl-bis(methylene)dimalonic acid
Brand: MedChemExpress
SKU: HY-D0034
Rating: 5.0 (3 reviews)

Cat. No.: HY-D0034 Purity: 98.00%: Data Sheet
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9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABMDMA) is a biological dye and indicator used to detect singlet oxygen generation (SOG). 9,10-Anthracenediyl-bis(methylene)dimalonic acid is water-soluble derivative of anthracene. 9,10-Anthracenediyl-bis(methylene)dimalonic acid can be photobleached by singlet oxygen to its corresponding endoperoxide. This reaction can be monitored spectrophotometrically by recording the decrease of absorbance at 400 nm.

For research use only. We do not sell to patients.

CAS No. : 307554-62-7

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE 9,10-Anthracenediyl-bis(methylene)dimalonic acid

Bio/Physico-chemical Assay

: 9,10-Anthracenediyl-bis(methylene)dimalonic acid purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Mar 10:20:2901-2921. [Abstract]; The spectrum of ABDA (2 mM) absorbance treated with pure laser irradiation for different times in the absence of ICG-Lips.

: 9,10-Anthracenediyl-bis(methylene)dimalonic acid purchased from MedChemExpress. Usage Cited in: Front Chem. 2024 Jun 24:12:1417715. [Abstract]; Photodegradation of ABDA with Cur@ZIF-8@BA. The measurements were carried out under white light irradiation in PBS buffer.

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Description

In Vitro

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Preparation of ABMDMA Staining Working Solution:^[1]
ABMDMA in water was mixed with Pc4SNP or Pc4 to give a final concentration of 2 μM.
2. Detection of singlet oxygen generation:
2.1 In a typical procedure, 0.5 mL of ABMDMA water solution (0.07 mg/mL) was added to methylene blue (MB)-GO or MB water solutions both containing (MB/H₂O) to give the final ABMDMA concentration of 3.33 μg/mL.
2.2 Next, 1 mL of MB-GO/ABMDMA or MB/ABMDMA solutions were poured into open quartz cuvettes and irradiated with a 785 nm laser for 55 min. The reactions were monitored with UV-vis spectroscopy by recording an absorbance decrease at 400 nm (λ_max) at 5-min intervals.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.37

Formula

C₂₂H₁₈O₈

CAS No.

307554-62-7

Appearance

Solid

Color

Light yellow to yellow

Emission (Em)

407

Excitation (Ex)

380

SMILES

OC(C(C(O)=O)CC1=C(C=CC=C2)C2=C(CC(C(O)=O)C(O)=O)C3=C1C=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (243.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4368 mL	12.1841 mL	24.3683 mL
5 mM	0.4874 mL	2.4368 mL	4.8737 mL
10 mM	0.2437 mL	1.2184 mL	2.4368 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (278 KB) SDS (537 KB)

COA (254 KB) HNMR (275 KB) RP-HPLC (259 KB)

Handling Instructions (2659 KB)

References

[1]. M. Wojtoniszak, et al. Graphene oxide functionalized with methylene blue and its performance in singlet oxygen generation. July 2013, 48(7):2636-2639.

[2]. Zhao B, et al. Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):163-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4368 mL	12.1841 mL	24.3683 mL	60.9206 mL
	5 mM	0.4874 mL	2.4368 mL	4.8737 mL	12.1841 mL
	10 mM	0.2437 mL	1.2184 mL	2.4368 mL	6.0921 mL
	15 mM	0.1625 mL	0.8123 mL	1.6246 mL	4.0614 mL
	20 mM	0.1218 mL	0.6092 mL	1.2184 mL	3.0460 mL
	25 mM	0.0975 mL	0.4874 mL	0.9747 mL	2.4368 mL
	30 mM	0.0812 mL	0.4061 mL	0.8123 mL	2.0307 mL
	40 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.5230 mL
	50 mM	0.0487 mL	0.2437 mL	0.4874 mL	1.2184 mL
	60 mM	0.0406 mL	0.2031 mL	0.4061 mL	1.0153 mL
	80 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.7615 mL
	100 mM	0.0244 mL	0.1218 mL	0.2437 mL	0.6092 mL

9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9,10-Anthracenediyl-bis(methylene)dimalonic acid307554-62-7ABMDMAFluorescent DyeMOFsMetal-Organic FrameworksSinglet OxygenSOGABDAphotobleachingInhibitorinhibitorinhibit

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9,10-Anthracenediyl-bis(methylene)dimalonic acid (Synonyms: ABMDMA)

Customer Review

9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Antibodies

3 Publications Citing Use of MCE 9,10-Anthracenediyl-bis(methylene)dimalonic acid

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•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

Customer Review

9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Antibodies

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Complete Stock Solution Preparation Table

9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Classifications

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