1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. 9-Hydroxyellipticine hydrochloride

9-Hydroxyellipticine hydrochloride 

Cat. No.: HY-101775A
Handling Instructions

9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively.

For research use only. We do not sell to patients.

9-Hydroxyellipticine hydrochloride Chemical Structure

9-Hydroxyellipticine hydrochloride Chemical Structure

CAS No. : 52238-35-4

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Description

9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

IC50 & Target

Topoisomerase II

 

In Vitro

9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM[4].

In Vivo

9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1].

Animal Model: Three- to five-month-old C57B1/6 male mice[1].
Dosage: 5 or 10 mg/kg.
Administration: IP.
Result: Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
Molecular Weight

298.77

Formula

C₁₇H₁₅ClN₂O

CAS No.

52238-35-4

SMILES

OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

9-HydroxyellipticineTopoisomerase9HEp53cancerInhibitorinhibitorinhibit

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9-Hydroxyellipticine hydrochloride
Cat. No.:
HY-101775A
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