2. Neuronal Signaling
  3. Amyloid-β
  4. BF-168

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

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BF-168

BF-168 화학구조

CAS No. : 634911-47-0

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5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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BF-168 Related Antibodies

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제품 설명

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

IC50 & Target

Ki: 6.4 nM (Aβ1-42)[1].
In Vitro

BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BF-168 Related Antibodies
In Vivo

Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [18F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

312.34

화학식

C18H17FN2O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CNC1=CC=C(/C=C/C2=NC3=CC=C(OCCF)C=C3O2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

용액&용해도
In Vitro: 

DMSO : 50 mg/mL (160.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2016 mL 16.0082 mL 32.0164 mL
5 mM 0.6403 mL 3.2016 mL 6.4033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2016 mL 16.0082 mL 32.0164 mL 80.0410 mL
5 mM 0.6403 mL 3.2016 mL 6.4033 mL 16.0082 mL
10 mM 0.3202 mL 1.6008 mL 3.2016 mL 8.0041 mL
15 mM 0.2134 mL 1.0672 mL 2.1344 mL 5.3361 mL
20 mM 0.1601 mL 0.8004 mL 1.6008 mL 4.0020 mL
25 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2016 mL
30 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6680 mL
40 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0010 mL
50 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
60 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
80 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0005 mL
100 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8004 mL
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BF-168 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BF-168634911-47-0BF168BF 168Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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Inquiry Information

상품명:
BF-168
Cat. No.:
HY-112830
수량:
MCE Japan Authorized Agent:

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