1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. Elesclomol

Elesclomol (Synonyms: STA-4783)

製品番号: HY-12040 純度: 99.80%
取扱説明書

Elesclomol (STA-4783) is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol shows antitumor activity against a broad range of cancer cell types. Elesclomol is also a highly lipophilic Cu2+-binding molecule. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.

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Elesclomol 構造式

Elesclomol 構造式

CAS 番号 : 488832-69-5

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
Solution
10 mM * 1 mL in DMSO USD 132 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 132 在庫あり
Estimated Time of Arrival: December 31
Solid
5 mg USD 120 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 720 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1140 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Elesclomol purchased from MCE. Usage Cited in: Biomolecules. 2019 Jul 24;9(8):298. 

    Confocal images of MitoSOX fluorescence intensity in CV-1 cells at the 20-min time point after E:C (elesclomol:copper)- treatment in the presence and absence of the mitochondrial superoxide scavenger MitoTEMPO.
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    製品説明

    Elesclomol (STA-4783) is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol shows antitumor activity against a broad range of cancer cell types. Elesclomol is also a highly lipophilic Cu2+-binding molecule. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2].

    体外実験

    Elesclomol (200 nM; 18 hours) treatment increases the number of early and late apoptotic cells in HSB2 cells. Elesclomol induces apoptosis in cancer cells through the induction of oxidative stress[1].
    Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 cells with IC50 values of 110 nM, 24 nM and 9 nM, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Apoptosis Analysis[1]

    Cell Line: HSB2 cells
    Concentration: 200 nM
    Incubation Time: 18 hours
    Result: Increased the number of early and late apoptotic cells.
    体内実験

    Elesclomol (10 mg/kg; subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54) treatment ameliorates severe cardiac pathology with a partial reduction in hypertrophy. Cardiac [Cu] increased with Elesclomol treatment from a vehicle knockout level of 34 to 55%[2].
    Elesclomol escorted copper to the mitochondria and increased cytochrome c oxidase levels in the brain. Elesclomol prevents detrimental neurodegenerative changes and improved the survival of the mottled-brindled mouse[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Cardiac Ctr1 knockout mice[2]
    Dosage: 10 mg/kg
    Administration: Subcutaneous injection; every three days from post-natal day 5 to 26 and once weekly until post-natal day 54
    Result: Ameliorated severe cardiac pathology with a partial reduction in hypertrophy.
    臨床実験
    分子量

    400.52

    分子式

    C₁₉H₂₀N₄O₂S₂

    CAS 番号
    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 22 mg/mL (54.93 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4968 mL 12.4838 mL 24.9675 mL
    5 mM 0.4994 mL 2.4968 mL 4.9935 mL
    10 mM 0.2497 mL 1.2484 mL 2.4968 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献

    純度: 99.80%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    製品名:
    Elesclomol
    製品番号:
    HY-12040
    数量:
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