1. Apoptosis
  2. Apoptosis
  3. Elesclomol

Elesclomol (Synonyms: STA-4783)

製品番号: HY-12040 純度: 99.80%
取扱説明書

Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis.

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Elesclomol 構造式

Elesclomol 構造式

CAS 番号 : 488832-69-5

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1  mL in DMSO USD 132 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 120 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 720 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1140 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Elesclomol purchased from MCE. Usage Cited in: Biomolecules. 2019 Jul 24;9(8). pii: E298. 

    Confocal images of MitoSOX fluorescence intensity in CV-1 cells at the 20-min time point after E:C (elesclomol:copper)- treatment in the presence and absence of the mitochondrial superoxide scavenger MitoTEMPO.
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    製品説明

    Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis.

    体外実験

    Elesclomol significantly induces the expression of heat shock stress response genes and metallothionein genes, a signature transcription profile indicative of oxidative stress in Hs294T cells. Elesclomol (100 nM) rapidly induces Hsp70 RNA levels with a 4.8-fold increase at 1 hour and a 160-fold increase at 6 hours in Ramos Burkitt's lymphoma B cells in consistent with the intracellular ROS content which increases by 20% as early as 0.5 hour and 385% at 6 hours, and the induction of Hsp70 can be blocked by antioxidants N-acetylcysteine (NAC) and Tiron pretreatment. Elesclomol increases the number of early and late apoptotic cells with 3.7- and 11-fold through the induction of oxidative stress, which can be completely blocked by NAC, while having little effect on normal cells[1]. Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 with IC50 of 110 nM, 24 nM and 9 nM, respectively[2]. Elesclomol induces copper-dependent ROS generation and cytoxicity in yeast. Instead of working through a specific cellular protein target, elesclomol interacts with the electron transport chain (ETC), a biologically coherent set of processes occurring in the mitochondrion, to generate high levels of ROS within the organelle and consequently cell death[3].

    体内実験

    Although elesclomol (25-100 mg/kg) shows no antitumor activity in nude mouse xenograft models of human breast cancers (MDA435, MCF7 and ZR-75-1), lung cancer (RER) or lymphoma (U937). Elesclomol substantially enhances the efficacy of chemotherapeutic agents such as paclitaxel in these models, both in terms of tumor regression and extended survival of mice[4].

    臨床実験
    分子量

    400.52

    分子式

    C₁₉H₂₀N₄O₂S₂

    CAS 番号

    488832-69-5

    SMILES

    S=C(C1=CC=CC=C1)N(NC(CC(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 22 mg/mL (54.93 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4968 mL 12.4838 mL 24.9675 mL
    5 mM 0.4994 mL 2.4968 mL 4.9935 mL
    10 mM 0.2497 mL 1.2484 mL 2.4968 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献
    細胞実験
    [3]

    For viability assays, HBL and HBL-ρ0 cells are incubated with 300 nM elesclomol-Cu or Cu for 24 h. Cell death is determined using propidium iodide (5 µg/mL in PBS) staining and FACS analysis. Inner mitochondrial transmembrane potential is measured by incubating cells (25×104/mL) with 40 nM DIOC6(3) for 15 minutes at 37°C immediately prior to flow cytometry.

    MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

    参考文献

    純度: 99.80%

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    ElesclomolSTA-4783STA4783STA 4783ApoptosisInhibitorinhibitorinhibit

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    製品名:
    Elesclomol
    製品番号:
    HY-12040
    数量:
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