2. VP-14637

MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.

For research use only. We do not sell to patients.

VP-14637 Chemical Structure

VP-14637 Chemical Structure

CAS No. : 235106-62-4

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VP-14637 Related Antibodies

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Description

MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.

IC50 & Target

IC50: 1.42 ng/mL (RSV)[1]
In Vitro

MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VP-14637 Related Antibodies
Molecular Weight

510.51

Formula

C25H22N10O3
CAS No.
SMILES

OC1=C(C(C2=CC=C(O)C=C2)C3=C(O)C=CC(/C=N/N4C(C)=NN=N4)=C3)C=C(/C=N/N5C(C)=NN=N5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Cell Assay
[1]

The laboratory and clinical isolates of RSV and various concentrations (ranging from 0.1 μM to 31.6 pM) of MDT‐637 (or ribavirin) are added to the HEp-2 cell monolayers at the same time. After 72 hours of incubation at 37°C, the cells and supernatants are harvested. An aliquot is immediately serially diluted and used for plaque assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VP-14637235106-62-4MDT-637VP14637VP 14637MDT637MDT 637Inhibitorinhibitorinhibit

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