Maltitol
Based on 1 Customer Validation
Maltitol is an orally active polyol and sugar alcohol sweetener produced by the hydrogenation of maltose. Maltitol can replace sucrose and has characteristics of having a minor impact on blood sugar and potential prebiotic effects.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 585-88-6
- Formula: C12H24O11
- Molecular Weight:344.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Maltitol (2.5-10 g/kg; intraperitoneal injection; single dose) is not genotoxic and not cytotoxic (to bone marrow cells) in rats. It does not induce chromosomal aberrations and does not reduce the mitotic index[3].
Maltitol (1-4 g/kg; intraperitoneal injection; 7 days) is not teratogenic in pregnant rats, but at the highest dose (4 g/kg), it reduces fetal weight and causes growth retardation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old C57BL/6 male mice treated high-fat diet[2]
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Dosage:5.0%
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Administration:Diet administration; 8 weeks
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Result:Significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.
Decreased the expression of sterol regulatory element-binding protein 1c (SREBP1c) mRNA.
Increased the expressions of farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase in the liver.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 585-88-6
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Appearance Solid
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Molecular Weight 344.31
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Formula C12H24O11
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Color White to off-white
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SMILES
O[C@H](CO)[C@H]([C@H](O)[C@H](CO)O)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 175 mg/mL (508.26 mM; Need ultrasonic)
DMSO : 33.33 mg/mL (96.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Saraiva A, et al. Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts. Int J Environ Res Public Health. 2020 Jul 20;17(14):5227. [Content Brief]
[2]. Urushima H, et al. Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets. J Med Food. 2015 Oct;18(10):1081-7. [Content Brief]
[3]. Canimoglu S, et al. The genotoxic and teratogenic effects of maltitol in rats. Toxicol Ind Health. 2013 Nov;29(10):935-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 2.9044 mL | 14.5218 mL | 29.0436 mL | 72.6090 mL |
| 5 mM | 0.5809 mL | 2.9044 mL | 5.8087 mL | 14.5218 mL | |
| 10 mM | 0.2904 mL | 1.4522 mL | 2.9044 mL | 7.2609 mL | |
| 15 mM | 0.1936 mL | 0.9681 mL | 1.9362 mL | 4.8406 mL | |
| 20 mM | 0.1452 mL | 0.7261 mL | 1.4522 mL | 3.6304 mL | |
| 25 mM | 0.1162 mL | 0.5809 mL | 1.1617 mL | 2.9044 mL | |
| 30 mM | 0.0968 mL | 0.4841 mL | 0.9681 mL | 2.4203 mL | |
| 40 mM | 0.0726 mL | 0.3630 mL | 0.7261 mL | 1.8152 mL | |
| 50 mM | 0.0581 mL | 0.2904 mL | 0.5809 mL | 1.4522 mL | |
| 60 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2101 mL | |
| 80 mM | 0.0363 mL | 0.1815 mL | 0.3630 mL | 0.9076 mL | |
| H2O | 100 mM | 0.0290 mL | 0.1452 mL | 0.2904 mL | 0.7261 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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