Infection

Asparenomycin A is a carbapenem antibiotic with strong β-lactamase inhibition activities.

Mycoplanecin B is a cyclic peptide antibiotic.

2-Chloro-2′-deoxyadenosine monophosphate is an anticoronavirus agent. It exhibits significant inhibitory effects against wild-type novel coronavirus, novel coronavirus variants (Beta, Delta, and Omicron strains), and other coronaviruses such as human coronavirus 229E, human coronavirus OC43, human coronavirus NL63, and mouse coronavirus MHV.

TH7299 is a TbFolD inhibitor with antiparasitic activity. TH7299 binds the tetrahydrofolate-binding pocket of MTHFD2, and inhibits MTHFD2L and the dehydrogenase/cyclohydrolase domain of MTHFD1. TH7299 reduces cancer cells viability, induces apoptosis, DNA damage. TH7299 can be used for the researches of african trypanosomiasis and acute myeloid leukemia.

Riamilovir is an oral, broad-spectrum antiviral agent. Riamilovir can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2.

20-Deoxynarasin has anti-Gram-positive bacteria, mycoplasma, coccidia and virus activity, and has effect on growth promotion.

Rifamycin L has the antibacterial action.

CP-5068is a cell wall inhibitor that can be used for the study of infectious diseases.

AR-709 is a diaminopyrimidine antibiotic. AR-709 exhibits potent antibacterial activity against Streptococcus pneumoniae (MIC = 0.03 mg/L). AR-709 can be used for research on bacterial infections.

Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.

N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum.

Thianthrene (Standard) is the analytical standard of Thianthrene. This product is intended for research and analytical applications. Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC₅₀ = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo.

(E)-Antibacterial agent 210 is the isomer of Antibacterial agent 210 (HY-163508). Antibacterial agent 210 is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR.

3,5-Dimethoxybenzoic acid (Standard) is the analytical standard of 3,5-Dimethoxybenzoic acid (HY-W001251). This product is intended for research and analytical applications. 3,5-Dimethoxybenzoic acid is an aromatic organic acid and antifungal agent. 3,5-Dimethoxybenzoic acid can also be used as an intermediate for anticancer agents. 3,5-Dimethoxybenzoic acid can be isolated from the leaves of Melia azedarach. 3,5-Dimethoxybenzoic acid exhibits antifungal activity against A. rabiei with an MIC of 0.125 mg/mL. 3,5-Dimethoxybenzoic acid has anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects.

Benzyl isothiocyanate (Standard) is the analytical standard of Benzyl isothiocyanate. This product is intended for research and analytical applications. Benzyl isothiocyanate is an orally available isothiocyanate with bactericidal, anticancer, antiangiogenic and anthelmintic activities. Benzyl isothiocyanate exerts anticancer functions by regulating multiple signaling pathways, including apoptosis, cell proliferation, cell cycle arrest, metastasis, angiogenesis, and autophagy. In addition, Benzyl isothiocyanate can enhance muscle insulin sensitivity to improve obesity-induced hyperglycemia[1][2][3][4][5][6][7][8][9].

NSC116565 is an Antibacterial agent, Herbicide, and competitive Ketol-acid reductoisomerase inhibitor, with a K_i of 95.4 nM against Mycobacterium tuberculosis MtKARI. NSC116565 inhibits the growth of mycobacteria by disrupting the branched-chain amino acid biosynthesis pathway, and also inhibits the growth of weeds and brassicas. NSC116565 can be used in tuberculosis-related research.

Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.

NVP-BHS345 is an ATP-competitive TORC1/TORC2 inhibitor with an IC₅₀ of 1 μM for both targets in yeast. NVP-BHS345 acutely inhibits TORC1/TORC2 kinase activity, even in genetically engineered TOR1^M2282T Saccharomyces cerevisiae strains. NVP-BHS345 also reduces the phosphorylation levels of Ser-232/Ser-233 sites in Sch9, Ypk1/Ypk2 and Rps6, and induces hyperphosphorylation of Slt2 and activation of the cell wall integrity pathway. NVP-BHS345 causes depolarization of the actin cytoskeleton, blocks fluid-phase endocytosis, prevents the accumulation of vacuolar lipophilic dyes, and regulates the phosphorylation levels of Ent1, Pan1, Prk1, Akl1 and other cellular proteins.

Leptosperin is a glycoside of methyl syringate found in manuka honey derived from the Leptospermum species Leptospermum scoparium. Leptosperin exhibits antibacterial activity. Leptosperin can be used for the research of infection.

Morin monohydrate, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation.