Infection

Tetrahydrofuryl alcohol is a synthetic tetrahydrofuran compound that exhibits no antifeedant or insecticidal activity against Spodoptera exigua larvae. Tetrahydrofuryl alcohol and its analogs can be used in studies related to pest control.

R-61837 is a synthetic antirhinoviral compound with significant in vitro activity. R-61837 is 10 times and 57 times more active against human rhinovirus type 9 (HRV-9) than Enviroxime and dichloroflavone (DCF), respectively, and is more active against human rhinovirus type 2 (HRV-2 ) were 5 times and 10 times higher respectively.

Artemitin (Standard) is the analytical standard of Artemitin. This product is intended for research and analytical applications. Artemitin is a flavonol found in Laggera pterodonta (DC.) Benth., with antioxidative, anti-inflammatory, and antiviral activity.

GKL003 is a bacterial transcription inhibitor that targets the RNAP-σ interaction interface, with a K_i of 5.79 nM. GKL003 specifically binds to the RNAP β' clamp helix region at the σ^A factor binding site, blocks the formation of RNAP holoenzyme, and inhibits the formation of bacterial transcription initiation complexes. GKL003 inhibits the growth of both Gram-positive and Gram-negative bacterial cells, and also exhibits activity against drug-resistant strains.

Luliconazole-¹³C₇ (NND 502-¹³C₇) is ¹³C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al.

1-Pentadecanol (Standard) is the analytical standard of 1-Pentadecanol (HY-W004295). This product is intended for research and analytical applications. 1-Pentadecanol is a long-chain fatty alcohol found in the leaves of Solena amplexicaulis. 1-Pentadecanol shows antibacterial activity with a MIC of 20 μg/mL against Salmonella gallinarum. 1-Pentadecanol can be used for the research of Salmonella gallinarum infection.

Oximidine III is an anti-tumor antibiotic. Oximidine III can selectively inhibit the growth of 3Y1 in rat fibroblasts with degeneration of various tumor genes. Oximidine III inhibits v-H-ras-3Y1, v-src-3Y1 cells and the normal 3Y1 cells with IC₅₀s (nM) of 14, 4.5 and 140, respectively. Oximidine III stops RAS-or SRC-denatured cells at G1 phase of the cell cycle and increases p21WAF1 expression.

Antibacterial agent 307 is an antibacterial agent. Antibacterial agent 307 shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 can be used for the research of bacterial infection.

Finafloxacin-d₄ (hydrochloride) is deuterium-labeled Finafloxacin (hydrochloride) (HY-13451A).

Anti-GC1q R/C1QBP Antibody (60.11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human GC1q R/C1QBP. Anti-GC1q R/C1QBP Antibody (60.11) can neutralize GC1q R. Anti-GC1q R/C1QBP Antibody (60.11) can be used for the researches of cancer, infection and inflammation, such as MDA231 tumor and S. aureus induced infective endocarditis (IE).

N-Nonyldeoxynojirimycin (Standard) is the analytical standard of N-Nonyldeoxynojirimycin (HY-107532). This product is intended for research and analytical applications. N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC₅₀: 0.42 μM) and α-1,6-glucosidase (IC₅₀: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breaK_down, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci.

Dp2mT is a non-cytotoxic control compound, with an IC₅₀ of >3 μM for HIV-1 transcription inhibition and an IC₅₀ of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity.

Ketotifen-d₃ (HC 20-511-d₃) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.

Chrymutasin B is a glycosidic antitumor antibiotic. Chrymutasin B is cytotoxic.

Carbenoxolone disodium (Standard) is the analytical standard of Carbenoxolone disodium (HY-B1367). This product is intended for research and analytical applications. Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

SrtA-IN-1 (Compound T10) is an inhibitor of Streptococcus pyogenes sortase A (SpSrtA), with an IC₅₀ value of 0.7 μM. SrtA-IN-1 can be used in the research of the anti-infection field.

MMV693183 is an orally active inhibitor of Plasmodium falciparum acetyl-CoA synthetase (AcAS), with an IC₅₀ of 300 nM against Plasmodium falciparum. MMV693183 exhibits potent inhibitory activity against clinical isolates of malaria parasites, including Artemisinin (HY-B0094)-resistant strains. MMV693183 is metabolized in vivo into the active antimetabolite CoA-MMV693183, which exerts effects of killing asexual blood-stage parasites and blocking transmission to Anopheles mosquitoes by binding to and inhibiting the function of acetyl-CoA synthetase, thereby reducing the levels of acetyl-CoA and 4'-phosphopantetheine. In humanized mouse models, MMV693183 shows favorable in vivo efficacy, drug-like properties, and no significant cytotoxicity or off-target activity against human cells. MMV693183 is widely used in malaria-related research as a parasiticide and metabolic disruptor.

Antimicrobial agent-50 is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC₅₀ of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC₅₀ values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively.

Temafloxacin (Standard) is the analytical standard of Temafloxacin. This product is intended for research and analytical applications. Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections.

Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.