1415648-20-2
Chemical Structure
TH7299
- CAS No.: 1415648-20-2
- Formula:C17H19N7O7
- Molecular Weight:433.38
IUPAC Name: (4-(3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)ureido)benzoyl)-L-glutamic acid
InChIKey: WBQDVZMETQWVQD-VIFPVBQESA-N
SMILES: N(C(NC1=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)=O)C2=C(N)NC(N)=NC2=O
Biological Activity: TH7299 is a TbFolD inhibitor with antiparasitic activity. TH7299 binds the tetrahydrofolate-binding pocket of MTHFD2, and inhibits MTHFD2L and the dehydrogenase/cyclohydrolase domain of MTHFD1. TH7299 reduces cancer cells viability, induces apoptosis, DNA damage. TH7299 can be used for the researches of african trypanosomiasis and acute myeloid leukemia.[1][2]
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TH7299 | TH7299 is a TbFolD inhibitor with antiparasitic activity. TH7299 binds the tetrahydrofolate-binding pocket of MTHFD2, and inhibits MTHFD2L and the dehydrogenase/cyclohydrolase domain of MTHFD1. TH7299 reduces cancer cells viability, induces apoptosis, DNA damage. TH7299 can be used for the researches of african trypanosomiasis and acute myeloid leukemia. | |||||||||||||||||||||
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- [1]. Eadsforth TC, et al. Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity. J Med Chem. 2015;58(20):7938-7948. [Content Brief]
- [2]. Bonagas N, et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer. 2022;3(2):156-172. [Content Brief]
Keywords
