Infection

Pyrisulfoxin A is an antibiotic found in Streptomyces callfornicus BS-75.

4-Methyl-6,7-methylenedioxycoumarin (4-Methylayapin) is a Coumarin (HY-N0709) derivative. 4-Methyl-6,7-methylenedioxycoumarin exhibits antifungal activity against Pythium sp..

Efavirenz-d₅ (DMP 266-d₅) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture. Efavirenz-d₅ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cladosporide B is found in the strain of Cladosporium sp. IFM 49189. Cladosporide B has slightly stronger anti-Aspergillus fumigatus activity than Cladosporide A.

Tamarixin is flavonoid that isolated from Astragalus tanae Sosn that has hepatoprotective, antioxidant, anticancer, and antimicrobial activities.

2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12. X

Danoprevir (Standard) is the analytical standard of Danoprevir (HY-10238). This product is intended for research and analytical applications. Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM). Danoprevir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 0.05 μM.

Abikoviromycin is an inhibitor of polyketide synthase PKS1 of C. lagenarium and can be isolated from Streptomyces.

4-Phenylbutyric acid (Standard) is the analytical standard of 4-Phenylbutyric acid (HY-A0281). This product is intended for research and analytical applications. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC₅₀s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC₅₀ of 11 μM and 12 μM.

Nothramicin is an anthracycline antibiotic with anti-mycobacterial activity .

Ro 24-6778 is a cephalosporin composed of Desacetylcefotaxime (HY-126129) and Desmethylfleroxacin ester-linked. Ro 24-6778 has high antibacterial activity against a wide range of aerobic bacteria.

Baquiloprim (Standard) is the analytical standard of Baquiloprim (HY-19581). This product is intended for research and analytical applications. Baquiloprim is an orally active Antibiotic and selective inhibitor of Bacterial Dihydrofolate reductase (DHFR), with an IC₅₀ of 19 nM against E. coli and an IC₅₀ of 190 μM against rat liver dihydrofolate reductase. Baquiloprim is a bacteriostatic broad-spectrum antibacterial agent that acts against Gram-negative and Gram-positive bacteria. Baquiloprim inhibits glucuronidation in cultured hepatocytes. Baquiloprim can be used in research related to Pasteurella haemolytica infection, bacterial infection, Escherichia coli diarrhea, bacterial infection in pigs, and pneumonic pasteurellosis.

N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum.

Antibiofilm agent-17 is a dual-action biofilm inhibitor against Pseudomonas aeruginosa (IC₅₀ = 0.33 μM). Antibiofilm agent-17 inhibits biofilm growth by reducing quorum sensing-mediated virulence production and iron ion acquisition. Antibiofilm agent-17 exhibits synergistic antimicrobial effects in a mouse wound infection model. Antibiofilm agent-17 can be used in research on combating Pseudomonas aeruginosa infections.

Antibacterial agent 263 (compound 5a) is a potent antibacterial agent. Antibacterial agent 263 shows antibacterial activity for Streptococcus mutans, Staphylococcus aureus.

Fluvirucin B1 is an antibiotic against influenza A virus.

Parvodicin A is a glycopeptide antibiotic. Parvodicin A has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis.

Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 34.81μM.

(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity.