Shogaol (Synonyms: [6]-Shogaol; 6-Shogaol)

製品番号: HY-14616 純度: 99.78%: FAQs
Data Sheet SDS COA 取扱説明書

Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Shogaol 構造式

CAS 番号 : 555-66-8

容量	価格（税別）	在庫状況	数量
Solution
10 mM * 1 mL in DMSO	USD 170	在庫あり	Estimated Time of Arrival: December 31
Liquid + Solvent
10 mM * 1 mL ready for reconstitution	USD 170	在庫あり	Estimated Time of Arrival: December 31
Liquid
1 mg	USD 56	在庫あり	Estimated Time of Arrival: December 31
5 mg	USD 119	在庫あり	Estimated Time of Arrival: December 31
10 mg	USD 198	在庫あり	Estimated Time of Arrival: December 31
25 mg	USD 396	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
プロトコル
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

体外実験

Shogaol ([6]-Shogaol) has anticancer activity against several cell lines^[1]. Shogaol ([6]-Shogaol) is identified to be cytotoxic in various cell lines, with KB (IC₅₀=7.4±2.2 μM) and HL60 (IC₅₀=7.9±2.0 μM) cells most susceptible to 6-shogaol^[2]. 6-shogaol (IC₅₀=8 μM) has much stronger growth inhibitory effects than 6-gingerol (IC₅₀=150 μM) on HCT-116 human colon cancer cells^[3]. Shogaol ([6]-Shogaol) stimulates phosphorylations of mitogen-activated protein kinases (MAPKs) such as ERK, JNK, and p38. Moreover, the 6-shogaol-induced expressions of Nrf2 and HO-1 are attenuated by treatments of SB202190 (a p38 specific inhibitor) and LY294002 (an Akt specific inhibitor)^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

The Shogaol ([6]-Shogaol) decreases the diethylnitrosamine (DEN)-mediated elevations of serum aspartate transaminase and alanine transaminase as well as the DEN-induced hepatic lipid peroxidation. Inductions of Nrf2 and HO-1 by 6-shogaol are also confirmed in the mice. The administration of Shogaol ([6]-Shogaol) to the mice also restores the DEN-reduced activity and protein expression of hepatic antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and catalase^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

276.37

Appearance

Liquid

分子式

C₁₇H₂₄O₃

CAS 番号

555-66-8

SMILES

OC1=C(OC)C=C(CCC(/C=C/CCCCC)=O)C=C1

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : ≥ 50 mg/mL (180.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6183 mL	18.0917 mL	36.1834 mL
5 mM	0.7237 mL	3.6183 mL	7.2367 mL
10 mM	0.3618 mL	1.8092 mL	3.6183 mL

*Please refer to the solubility information to select the appropriate solvent.

体内:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

*All of the co-solvents are available by MCE.

純度とドキュメンテーション

純度: 99.84%

Select Batch:

データシート (273 KB) SDS (392 KB)

COA (243 KB) HNMR (179 KB) LCMS (300 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Semwal RB, et al. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015 Sep;117:554-68. [Content Brief]

[2]. Peng F, et al. Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia. 2012 Apr;83(3):568-85. [Content Brief]

[3]. Sang S, et al. Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J Agric Food Chem. 2009 Nov 25;57(22):10645-50. [Content Brief]

[4]. Bak MJ, et al. 6-shogaol-rich extract from ginger up-regulated the antioxidant defense systems in cells and mice. Molecules. 2012 Jul 4;17(7):8037-55. [Content Brief]

細胞実験 ^[4]	The effects of 6-shogaol on the viability of HepG2 cells are determined by a MTT assay after 24 h treatment. The data are expressed as percent cell viability compared to that of control. The concentrations of the treatments 6-shogaol varied from 10 to 100 μg/mL^[4]. MCE はこれらの方法の精度を確認していません。こちらは参照専用です。
動物実験 ^[4]	Mice: Male Balb/c mice are treated with 6-shogaol-rich ginger extracts (10 and 100 mg/kg b.w.) or silymarin (100 mg/kg b.w.), a positive control, and challenged with diethyl-nitrosoamine (DEN, 30 mg/kg b.w.) 3 days per week for 3 weeks^[4]. MCE はこれらの方法の精度を確認していません。こちらは参照専用です。
参考文献	[1]. Semwal RB, et al. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015 Sep;117:554-68. [Content Brief] [2]. Peng F, et al. Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia. 2012 Apr;83(3):568-85. [Content Brief] [3]. Sang S, et al. Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J Agric Food Chem. 2009 Nov 25;57(22):10645-50. [Content Brief] [4]. Bak MJ, et al. 6-shogaol-rich extract from ginger up-regulated the antioxidant defense systems in cells and mice. Molecules. 2012 Jul 4;17(7):8037-55. [Content Brief]

Shogaol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

モル濃度カルキュレーター
希釈カルキュレーター

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Shogaol555-66-8[6]-Shogaol 6-ShogaolAutophagyInhibitorinhibitorinhibit

最近チェックした製品:

製品名

タイトル

お名前 *

PC 用メールアドレス *

電話番号 *

勤務先/学校名 *

Department *

カスタマ需要量 *

国会或いは地域 *

必ず会社名を記載ください。個人への返信は行いません。

メッセージ

製品名			Lot #
お名前 *			PC 用メールアドレス *
電話番号 *			部門 *
勤務先/学校名 *			国会或いは地域 *
メッセージ

Name
メール *

	Sorry, but the email address you supplied was invalid.

Shogaol (Synonyms: [6]-Shogaol; 6-Shogaol)

カスタマーレビュー

Shogaol 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

プロトコル

純度とドキュメンテーション

参考文献

カスタマーレビュー

Shogaol 関連抗体

Shogaol Related Classifications

モル濃度カルキュレーター

希釈カルキュレーター

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report