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Cat. No.: HY-P1485

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Substance P(1-7)

Name: Substance P(1-7)
Brand: MedChemExpress
SKU: HY-P1485
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

For research use only. We do not sell to patients.

CAS No.: 68060-49-1
Formula: C₄₁H₆₅N₁₃O₁₀
Molecular Weight:900.04

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Please store the product under the recommended conditions in the Certificate of Analysis.

Substance P(1-7) Chemical Structure

CAS No.: 68060-49-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Publications (1)
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Biological Activity

Description

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius^[1].

All Neurokinin Receptor Isoforms :

In Vivo

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions^[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 68060-49-1
Molecular Weight 900.04
Formula C₄₁H₆₅N₁₃O₁₀
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe
Sequence Shortening

RPKPQQF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Dermatol Sci

2026 Aug;123(2):63-74. PMID: 42251015

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20. [Content Brief]

[2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Substance P(1-7)

1 Cited Publications

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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Substance P(1-7)

Publications Citing Use of MedChemExpress (MCE) Substance P(1-7)

All Neurokinin Receptor Isoforms