3β-HSD Inhibitor

Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer.

HEAL-116 is a potent, specific and orally active 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor with an IC₅₀ of 1.18 μM and a K_D of 1.32 μM. HEAL-116 inhibits DHEA (HY-14650) metabolism and DHEA-induced target gene expression and cell proliferation. HEAL-116 can be used for cancer research, such as prostate cancer.

Trilostane-¹⁵N,d₃ (Win 24540-¹⁵N,d₃) is the deuterium labeled Trilostane (HY-14281). Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer.

3βHSD1-IN-1 (Compound 46) is a 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) inhibitor with an IC₅₀ of 55 nM. 3βHSD1-IN-1 can effectively inhibit androgen receptor activity. 3βHSD1-IN-1 can be used in the research of diseases such as prostate cancer.