2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor
  5. 5-HT3 Receptor Isoform
  6. 5-HT3 Receptor Antagonist

5-HT3 Receptor Antagonist

5-HT3 Receptor Antagonists (49):

Cat. No. Product Name Effect Purity
  • HY-14564A
    GTS-21 dihydrochloride
    		Antagonist 99.92%
    GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities.
  • HY-14541
    Olanzapine
    		Antagonist 99.83%
    Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
  • HY-B0002B
    Ondansetron
    		Antagonist 99.46%
    Ondansetron(GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
  • HY-101062
    3-AQC
    		Antagonist
    3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist.
  • HY-19283
    DU125530
    		Antagonist
    DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively.
  • HY-15419
    RS-127445 hydrochloride
    		Antagonist 99.58%
    RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5.
  • HY-B0352
    Mirtazapine
    		Antagonist 99.97%
    Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent.
  • HY-103152
    GR 113808
    		Antagonist 99.96%
    GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8).
  • HY-B0002A
    Ondansetron hydrochloride dihydrate
    		Antagonist 99.03%
    Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier).
  • HY-70050C
    Alosetron Hydrochloride
    		Antagonist 99.79%
    Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist.
  • HY-A0021
    Palonosetron hydrochloride
    		Antagonist 99.94%
    Palonosetron hydrochloride is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
  • HY-B0068
    Azasetron hydrochloride
    		Antagonist 99.78%
    Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist.
  • HY-B0071A
    Granisetron Hydrochloride
    		Antagonist 99.90%
    Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
  • HY-B0020
    Tropisetron Hydrochloride
    		Antagonist 99.95%
    Tropisetron Hydrochloride (SDZ-ICS-930) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
  • HY-32329A
    Setiptiline maleate
    		Antagonist 98.18%
    Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist.
  • HY-A0008
    Talipexole dihydrochloride
    		Antagonist 99.88%
    Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
  • HY-B0750
    Dolasetron
    		Antagonist ≥98.0%
    Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
  • HY-B1541
    Bemesetron
    		Antagonist ≥99.0%
    Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM.
  • HY-B0595
    Ramosetron Hydrochloride
    		Antagonist 99.91%
    Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.
  • HY-14264
    Cyamemazine
    		Antagonist ≥99.0%
    Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore.