5-HT3 Receptor Antagonist
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GTS-21 dihydrochloride
0 ImagesSynonyms: DMXB-A; DMBX-anabaseineGTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
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Ricasetron
0 ImagesSynonyms: BRL-46470Ricasetron (BRL-46470) is a selective and orally active 5-HT3 receptor antagonist. Ricasetron displays little or no affinity for a variety of other neurotransmitter receptors. Ricasetron has anxiolytic and antiemetic effects.
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VUF10166
0 ImagesVUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM.
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KB R6933
0 ImagesCat. No.: HY-105449ACAS No.: 148565-09-7Synonyms: KB 6806 maleate
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5-HT3 antagonist-7
0 ImagesCat. No.: HY-182701CAS No.: 149685-89-25-HT3 antagonist-7 (Compound 7e) is a competitive and selective 5-HT3 receptor antagonist. 5-HT3 antagonist-7 inhibits 5-HT-induced contractions in guinea pig ileum and guinea pig thoracic aorta. 5-HT3 antagonist-7 prevents 2-methyl-5-HT-induced vomiting episodes in ferrets.
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MCI-225 hydrate hydrochloride
0 ImagesCat. No.: HY-120810CAS No.: 476148-82-0Synonyms: DDP-225 hydrate hydrochlorideMCI-225 (DDP-225) hydrate hydrochloride is a selective and orally active noradrenaline (NA) reuptake inhibitor with 5-HT3 receptor antagonism. MCI-225 hydrate hydrochloride has antidepressant-like and anxiolytic-like properties. MCI-225 hydrate hydrochloride can be used for the study of anxiety disorder.
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Batanopride
0 ImagesCat. No.: HY-183136CAS No.: 102670-46-2Synonyms: BMY 25801Batanopride (BMY 25801) is a selective 5-HT3 receptor antagonist. Batanopride inhibits chemotherapy-induced emesis, and prevents Cisplatin (HY-17394)-, Cyclophosphamide (HY-17420)-, Doxorubicin (HY-15142A)-, and total body irradiation-induced emesis.
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Tropanserin
0 ImagesSynonyms: MDL 72422Tropanserin is a serotoninergic active compound, as well as a 5HT3 receptor antagonist. Tropanserin modulates Cardio-respiratory reflex effects of an exogenous serotonin challenge.
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KF 18259
0 ImagesCat. No.: HY-105479CAS No.: 139094-48-7KF 18259 is a 5-HT3-receptor antagonist. KF 18259 inhibits the wrap-restraint stress-induced propulsive motility of the proximal and distal colon.
