155584-74-0
155584-74-0
Chemical Structure
VUF10166
- CAS No.: 155584-74-0
- Formula:C13H15ClN4
- Molecular Weight:262.74
IUPAC Name: 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline
InChIKey: FFXVTQDGTKEXHF-UHFFFAOYSA-N
SMILES: CN1CCN(C2=NC3=CC=CC=C3N=C2Cl)CC1
Biological Activity: VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VUF10166 | 99.83% | VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM. | ||||||||||||||||||||
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References
Keywords
