313984-77-9
313984-77-9
Chemical Structure
PU02
- No. CAS: 313984-77-9
- Formula:C16H12N4S
- Molecular Weight:292.36
IUPAC Name: 6-((naphthalen-1-ylmethyl)thio)-9H-purine
InChIKey: BGMSTNYJYPSLHN-UHFFFAOYSA-N
SMILES: C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2
Biological Activity: PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
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PU02 | 98.92% | PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-W0974536-(Methylthio)purine -
Similarity Score 0.50
HY-W285050(Naphthalen-1-ylmethyl)hydrazine hydrochloride -
Similarity Score 0.50
HY-B0941A6-Benzylaminopurine, suitable for plant cell culture -
Similarity Score 0.50
HY-W0172411-Naphthalenemethanol -
Similarity Score 0.50
HY-W014537RN-Methyl-1-(naphthalen-1-yl)methanamine hydrochloride (Standard) -
Similarity Score 0.49
HY-W0083381-Ethylnaphthalene -
Similarity Score 0.49
HY-W007897Terbinafine impurity 1 -
Similarity Score 0.49
HY-W0168762-(Naphthalen-1-yl)ethanol -
Similarity Score 0.49
![Benz[a]anthracene-7-methanol-<sup>13</sup>C<sub> Chemical Structure](//file.medchemexpress.com/product_pic/hy-w778774.gif)
HY-W778774Benz[a]anthracene-7-methanol-13C -
Explore the MedChemAI to find more analogs
![Benz[a]anthracene-7-methanol-<sup>13</sup>C<sub> Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w778774.gif)
References
- [1]. Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54. [Content Brief]
- [2]. Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695(1-3):27-33. [Content Brief]
