5-HT Receptor Agonist

Donitriptan (Standard) is the analytical standard of Donitriptan (HY-106157). This product is intended for research and analytical applications. Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pK_is of 9.4 and 9.3, respectively.

m-CPBG (hydrochloride) (Standard) is the analytical standard of m-CPBG (hydrochloride) (HY-100938). This product is intended for research and analytical applications. m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.

5-HTQ chloride is an indole alkaloid that can be isolated from the skin secretions of the Australian golden bell frog Litoria aurea. 5-HTQ chloride is also a full agonist of the 5-HT receptor.

CJ033466 (Standard) is the analytical standard of CJ033466 (HY-103108). This product is intended for research and analytical applications. CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC₅₀ of 9 nM and has gastroprokinetic effect.

CP-809101 is a potent and highly selective 5-HT_2C receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human 5HT_2C, 5HT_2B and 5HT_2A receptor. CP-809101 inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.

Enciprazine is an orally active non-benzodiazepine anxiolytic. Enciprazine acts as an agonist of 5-HT₁A receptor (5-HT₁AR) and an antagonist of α₁-adrenergic receptor (α1-adrenergic receptor) . Enciprazine induces drug-related electroencephalogram changes by reducing the average power of δ waves and θ waves, and increasing the average power of α waves and fast β waves. Enciprazine exhibits anti-aggressive activity, with only weak sedative and ataxic effects. Enciprazine regulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis. Enciprazine can be used in research related to anxiety disorders, generalized anxiety syndrome and psychosis.

CP 132484 is a rat 5-HT_2A receptor agonist with a K_i of 1.1 nM and an IC₅₀ of 2.8 nM, and it exhibits over 40-fold selectivity over rat 5-HT1A receptors and bovine 5-HT1D receptors. CP 132484 stimulates phosphoinositide hydrolysis and intracellular calcium mobilization. CP 132484 can be used for research into diseases such as glaucoma.

EMD386088 (Standard) is the analytical standard of EMD386088 (HY-103130). This product is intended for research and analytical applications. EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC₅₀ of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC₅₀ of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia.

5-Carboxamidotryptamine (maleate) (Standard) is the analytical standard of 5-Carboxamidotryptamine (maleate) (HY-100942). This product is intended for research and analytical applications. 5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist.

BMY 7378 (Standard) is the analytical standard of BMY 7378 (HY-100554). This product is intended for research and analytical applications. BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist.

Tandospirone (Standard) is the analytical standard of Tandospirone. This product is intended for research and analytical applications. Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.

5-Hydroxytryptamine creatinine sulfate monohydrate (Standard) is the analytical standard of 5-Hydroxytryptamine creatinine sulfate monohydrate (HY-W010973). This product is intended for research and analytical applications. 5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock.

5-HT4R agonist-3 is a 5-HT4R agonist with an EC₅₀ of 22 nM. 5-HT4R agonist-3 selectively modulates 5-HT4R and induces pro-cognitive activity. 5-HT4R agonist-3 can be used in research related to Alzheimer's disease.

LP-211 (Standard) is the analytical standard of LP-211 (HY-111455). This product is intended for research and analytical applications. LP-211 is a selective and blood brain barrier penetrant 5-HT7 receptor agonist, with a K_i of 0.58 nM, with high selectivity over 5-HT1A receptor (K_i, 188 nM) and D2 receptor (K_i, 142 nM).