CP 132484 

CP 132484 is a rat 5-HT_2A receptor agonist with a K_i of 1.1 nM and an IC₅₀ of 2.8 nM, and it exhibits over 40-fold selectivity over rat 5-HT1A receptors and bovine 5-HT1D receptors. CP 132484 stimulates phosphoinositide hydrolysis and intracellular calcium mobilization. CP 132484 can be used for research into diseases such as glaucoma^[1].

CP 132484 (Compound 4a) (1 h) binds with high affinity to rat cortical 5-HT_2A receptors, with a K_i of 1.1 nM and an IC₅₀ of 2.8 nM^[1].
CP 132484 (1 h) potently stimulates phosphoinositide hydrolysis in A7r5 rat vascular smooth muscle cells via activation of the 5-HT_2A receptor, with an EC₅₀ of 213 nM and a potency reaching 96% relative to serotonin^[1].
CP 132484 stimulates calcium mobilization in A7r5 rat vascular smooth muscle cells by activating the 5-HT_2a receptor, with an EC₅₀ of 95.5 nM and a potency equivalent to 70% of that of serotonin^[1].
CP 132484 (1 h) exhibits low affinity (IC₅₀ = 8410 nM) and no agonist activity at cloned human 5-HT_1A receptors expressed on CHO cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

230.31

C₁₄H₁₈N₂O

143508-76-3

O1C2=CC=C3C(C(=CN3C)CCN)=C2CCC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. May JA, et al. A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95.
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