Bcl-2 Family Ligand
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BMf-BH3
0 ImagesCat. No.: HY-P1733Purity: 99.48%Synonyms: BMF-YBMf-BH3 (BMF-Y) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 can be used in cancer-related research.
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A-1210477-piperazinyl
0 ImagesCat. No.: HY-125908CAS No.: 2351218-72-7Synonyms: PROTAC Mcl1-binding moiety 1A-1210477-piperazinyl is a compound binds to protein myeloid cell leukemia 1 (MCL1) used for PROTAC technology.
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c-MYC/BCL2 ligand 1 iodide
0 ImagesCat. No.: HY-174403c-MYC/BCL2 ligand 1 iodide is a dual-targeting c-MYC/Bcl-2 G4 ligand with Kd values of 0.90 μM (c-MYC G4) and 0.56 μM (Bcl-2 G4). c-MYC/BCL2 ligand 1 iodide inhibits c-MYC and Bcl-2 gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 iodide inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 iodide significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 iodide can be used for the research of breast cancer.
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BMf-BH3 TFA
0 ImagesCat. No.: HY-P1733ASynonyms: BMF-Y TFABMf-BH3 TFA (BMF-Y TFA) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 TFA binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 TFA can be used in cancer-related research.
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BCL-xL ligand 5
0 ImagesCat. No.: HY-184713CAS No.: 1235033-76-7BCL-xL ligand 5 is a Bcl-xL ligand with an IC50 of 0.5 nM. BCL-xL ligand 5 can be used for the synthesis of PROTACs, such as PROTAC Bcl-xL degrader-2 (HY-139309).
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BCL-xL ligand 4
0 ImagesCat. No.: HY-184547CAS No.: 3027548-08-6BCL-xL ligand 4 is a BCL-xL ligand that can be used for the synthesis of PROTACs, such as PZ703b (HY-115718), PZ703b TFA (HY-115718A), and PZ703b hydrochloride (HY-115718B).
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BCL-xL ligand 3
0 ImagesCat. No.: HY-185551CAS No.: 3053404-37-5BCL-xL ligand 3 is a BCL-xL PROTAC ligand. BCL-xL ligand 3 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize PROTAC Bcl-xL degrader-3 (HY-132997).
