CRFR
Corticotropin-releasing Factor Receptor; CRHR
The CRFR (Corticotropin-releasing Factor Receptor, CRHR) belongs to the G-coupled receptor superfamily. Two receptor subtypes, CRF1 receptor and CRF2 receptor, and several splice variants for both receptor subtypes have been discovered. CRF itself has a greater affinity for CRF1 receptors while urocortin 1 (Ucn 1) binds with high affinity to both receptors and Ucn 2 and Ucn 3 both preferentially bind to CRF2 receptors.
Two CRF receptor subtypes are encoded by distinct genes which exhibit diverse alternative pre-mRNA splicing patterns resulting in multiple variants derived from partial or total exon deletions or insertions. With regard to the nine human CRF1 variants, CRF1a-i, described, CRF1a being the main wild type functional receptor while the other isoforms may modulate CRF signaling. For the CRF2, three functionally active splice variants, CRF2a-c, have been described in humans.
CRFR Isoform Specific Products
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CRFR Related Products (90)
Related Products (90)
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CRFR Isoform Comparison
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Neuropeptide SF (human) acetate
0 ImagesCat. No.: HY-P1245ACAS No.: 2924824-03-1Synonyms: Neuropeptide NPFF (human) acetateNeuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
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NBI 35965 hydrochloride
0 ImagesCat. No.: HY-110056CAS No.: 1782228-59-4NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects.
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JNJ19567470
0 ImagesCat. No.: HY-107095CAS No.: 724471-26-5Synonyms: R317573; CRA5626; TAI041JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses.
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[Tyr0] Corticotropin Releasing Factor, ovine
![[Tyr0] Corticotropin Releasing Factor, ovine](https://file.medchemexpress.com/product_pic/hy-p3687.gif "Click to View [Tyr0] Corticotropin Releasing Factor, ovine Product Detail")
0 ImagesCat. No.: HY-P3687CAS No.: 83930-34-1[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.
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(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
0 ImagesCat. No.: HY-P4542CAS No.: 150646-45-0(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition.
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NGD 98-2
0 ImagesCat. No.: HY-114070CAS No.: 355836-54-3NGD 98-2 is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
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[DPro5] Corticotropin Releasing Factor, human, rat
![[DPro5] Corticotropin Releasing Factor, human, rat](https://file.medchemexpress.com/product_pic/hy-p3684.gif "Click to View [DPro5] Corticotropin Releasing Factor, human, rat Product Detail")
0 ImagesCat. No.: HY-P3684CAS No.: 195628-97-8[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.
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a-Helical Corticotropin Releasing Factor (9-41)
0 ImagesCat. No.: HY-P3169CAS No.: 99658-03-4α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo.
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Urocortin II, human TFA
0 ImagesCat. No.: HY-P1752AUrocortin II, human TFA is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human TFA has an effect of promoting satiet and neuroprotective effect. Urocortin II, human TFA also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human TFA can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human TFA can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human TFA can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
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E2508
0 ImagesCat. No.: HY-123677CAS No.: 685886-34-4E2508 is an orally active corticotropin-releasing factor 1 (CRF1) receptor antagonist with a Ki value of 11 nM for hCRF1.
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BMS-561388 benzenesulfonate
0 ImagesCat. No.: HY-12125CAS No.: 383368-51-2BMS-561388 benzenesulfonate is a corticotropin-releasing factor receptor (CRFR) antagonist. BMS-561388 benzenesulfonate can be used for the research of neurological disease, such as anxiety and depression.
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(Tyr0)-Urocortin, rat
0 ImagesCat. No.: HY-P3959CAS No.: 187111-93-9(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM.
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CP 316311
0 ImagesCat. No.: HY-14129CAS No.: 175139-41-0CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.
![[Met(O)21] Corticotropin Releasing Factor, ovine](https://file.medchemexpress.com/product_pic/hy-p3685.gif "Click to View [Met(O)21] Corticotropin Releasing Factor, ovine Product Detail")
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Sauvagine
0 ImagesCat. No.: HY-P1298CAS No.: 74434-59-6Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases.
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Stresscopin-related peptide (human)
0 ImagesCat. No.: HY-P3130CAS No.: 348626-74-4Stresscopin-related peptide (human) is a specific ligand for the type 2 CRH receptor. Stresscopin-related peptide (human) suppresses food intake, delayed gastric emptying and decreases heat-induced edema. Stresscopin-related peptide (human) maintains homeostasis after stress, and can be used in the research of stress-related diseases.
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Stresscopin (human)
0 ImagesCat. No.: HY-P2829CAS No.: 352020-03-2Stresscopin (human) is a selective ligand of type 2 adrenocorticotropin-releasing hormone (CRH) receptors and can be used in the research of stress-related diseases.
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R121919 (Standard)
0 ImagesCat. No.: HY-14127RCAS No.: 195055-03-9Synonyms: NBI30775 (Standard)R121919 (Standard) is the analytical standard of R121919. This product is intended for research and analytical applications. R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.
