724471-26-5
724471-26-5
Chemical Structure
JNJ19567470
Synonym(s): R317573; CRA5626; TAI041
- CAS No.: 724471-26-5
- Formula:C22H27BrN4O
- Molecular Weight:443.38
IUPAC Name: (1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)methanol
InChIKey: GGRHUOGLCCJDDN-UHFFFAOYSA-N
SMILES: BrC1=CC(C)=C(N2C=C(C)C3=C(N4CCC(CC4)CO)N=C(C)N=C32)C(C)=C1
Biological Activity: JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses[1][2].
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JNJ19567470 | JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses. | |||||||||||||||||||||
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References
- [1]. Shekhar A, et al. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses. Int J Neuropsychopharmacol. 2011 Apr;14(3):355-65. [Content Brief]
- [2]. Sotiriou I, et al. Pharmacotherapy in smoking cessation: Corticotropin Releasing Factor receptors as emerging intervention targets. Neuropeptides. 2017 Jun;63:49-57. [Content Brief]
