JNJ19567470
JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses.
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- CAS No.: 724471-26-5
- Formula: C22H27BrN4O
- Molecular Weight:443.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 724471-26-5
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Molecular Weight 443.38
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Formula C22H27BrN4O
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SMILES
BrC1=CC(C)=C(N2C=C(C)C3=C(N4CCC(CC4)CO)N=C(C)N=C32)C(C)=C1
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Synonyms
R317573; CRA5626; TAI041
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shekhar A, et al. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responses. Int J Neuropsychopharmacol. 2011 Apr;14(3):355-65. [Content Brief]
[2]. Sotiriou I, et al. Pharmacotherapy in smoking cessation: Corticotropin Releasing Factor receptors as emerging intervention targets. Neuropeptides. 2017 Jun;63:49-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ19567470 Related Classifications
HY-107095 Related Classifications
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