2. Signaling Pathways
  3. GPCR/G Protein
  4. CRFR
  5. CRFR Inhibitor

CRFR Inhibitor

CRFR Isoform Comparison

CRFR Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-113603
    Tildacerfont
    		Inhibitor 98.60%
    Tildacerfont (SPR001; LY2371712) is an orally active, blood-brain barrier-penetrant selective corticotropin-releasing factor type 1 (CRF1) receptor antagonist. Tildacerfont selectively blocks CRF1 receptors, thereby inhibiting the release of pituitary adrenocorticotropic hormone (ACTH). Tildacerfont can be used in research related to congenital adrenal hyperplasia.
  • HY-P1297
    CRF(6-33)(human)
    		Inhibitor 99.61%
    CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect.
  • HY-P3683
    a-Helical Corticotropin Releasing Factor (12-41)
    		Inhibitor
    a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.
  • HY-P1297A
    CRF(6-33)(human) TFA
    		Inhibitor
    CRF(6-33)(human) TFA is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) TFA competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) TFA has anti-obesity effect.