Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2751)
Related Products (2751)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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ECDG
0 ImagesCat. No.: HY-184103CAS No.: 378230-75-2Synonyms: Ethylenedicysteine deoxyglucoseECDG is a small-molecule compound dependent on α-ketoglutarate/Fe2+ that participates in the biosynthesis of echinocandins. ECDG is involved in the targeted transport of glucose, and can be used for PET imaging after labeling with radioactive atoms. ECDG increases blood glucose levels in rats, undergoes cellular uptake mediated by D-glucose, localizes in ischemic viable myocardial tissue, and accumulates in the synovial space of rheumatoid arthritis. ECDG can be used in research related to candidiasis, glucose metabolism disorders, fungal infections, myocardial ischemia and rheumatoid arthritis.
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Mafenide Acetate (Standard)
0 ImagesMafenide (Acetate) (Standard) is the analytical standard of Mafenide Acetate (HY-B0614A). This product is intended for research and analytical applications. Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds.
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(Gly0.8Nap0.2)20
0 ImagesCat. No.: HY-161457(Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity.
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Neocryptolepine-Cl
0 ImagesCat. No.: HY-173342CAS No.: 1150313-15-7Synonyms: Cryptotackieine-ClNeocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4 and exhibits excellent antifungal activity against B. cinerea with EC50 value of 0.56 μg/mL.
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SDH-IN-34
0 ImagesCat. No.: HY-178457SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection.
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Moracin B
0 ImagesCat. No.: HY-N12497CAS No.: 67259-16-9Moracin B is a phytoalexin with antifungal activity. Moracin B can be isolated from the cortex and phloem tissues of mulberry (Morus alba Linne) infected with Fusarium solani f. sp. mori. Moracin B can be used to study plant disease resistance mechanisms against microbial infections, particularly showing potential application value in the field of plant disease control.
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CYP51-IN-23-d3
0 ImagesCat. No.: HY-174353SCYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs).
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Triadimenol-d4
0 ImagesCat. No.: HY-B0851SCAS No.: 2121989-56-6Triadimenol-d4 is the deuterium labeled Triadimenol. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
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Destomycin B
0 ImagesCat. No.: HY-138194CAS No.: 11005-98-4Synonyms: A-16316-CDestomycin B (A-16316-C) is an antibiotic, and is active against fungi. Destomycin B also has anthelmintic activity.
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Lanomycin
0 ImagesCat. No.: HY-118451CAS No.: 141363-91-9Lanomycin is an antifungal compound with activity against Candida and dermatophytes.
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8-Acetylverrucarin L
0 ImagesCat. No.: HY-N13025CAS No.: 77101-88-3Synonyms: Verrucarin L acetate8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum.
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2-Methylheptanoic acid (Standard)
0 ImagesCat. No.: HY-W015664RCAS No.: 1188-02-92-Methylheptanoic acid (Standard) is the analytical standard of 2-Methylheptanoic acid (HY-W015664). This product is intended for research and analytical applications. 2-Methylheptanoic acid is a naturally occurring branched-chain medium-chain fatty acid with fumigant activity against Aspergillus flavus. 2-Methylheptanoic acid inhibits the growth of Aspergillus flavus and kills its spores via two modes of action, namely fumigation and direct contact, with its fumigant activity being stronger than its direct contact activity. 2-Methylheptanoic acid can be used in studies related to Aspergillus flavus infection.
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Pencycuron (Standard)
0 ImagesCat. No.: HY-B2048RCAS No.: 66063-05-6Pencycuron (Standard) is the analytical standard of Pencycuron. This product is intended for research and analytical applications. Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight.
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Aranochlor A
0 ImagesCat. No.: HY-N13951CAS No.: 208466-05-1Aranochlor A is an antibiotic found in Pseudoarachniotus roseus (HIL Y-30499). Aranochlor A exhibits antibacterial and antifungal activities.
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Phoslactomycin F
0 ImagesCat. No.: HY-N12675CAS No.: 122856-30-8Phoslactomycin F has weak effect against Gram-positive bacteria, but has strong effect against fungi.
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Arginomycin
0 ImagesCat. No.: HY-N13890CAS No.: 106133-33-9Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro.
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α-Thujaplicin
0 Imagesα-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma.
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Antifungal agent-162
0 ImagesCat. No.: HY-136753CAS No.: 1155361-01-5Antifungal agent-162 (Compound 1c) is an Antifungal agent. Antifungal agent-162 exhibits potent in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Candida krusei, and Microsporum gypseum (with MIC80 values ranging from 0.0156 to 0.25 μg/mL), while shows no activity against Aspergillus fumigatus.
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Pyrrolomycin B
0 ImagesCat. No.: HY-N14575CAS No.: 79763-00-1Pyrrolomycin B is a pyrrole antibiotic. Pyrrolomycin B has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
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Methfuroxam
0 ImagesCat. No.: HY-W714197CAS No.: 28730-17-8Methfuroxam is a fungicide that exhibits extremely high inhibitory activity against three important pathogenic fungi (C. salmonicolor, R. lignosus, Ganoderma sp.) of rubber trees and oil palms.
