Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2750)
Related Products (2750)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Chitosan-PEG-Cy3
0 ImagesCat. No.: HY-D2430Chitosan-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, Chitosan and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Chitosan exhibits antimicrobial activity against various bacteria and fungi.
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Pramiconazole
0 ImagesSynonyms: Azoline; R126638Pramiconazole is a broad-spectrum antifungal agent with oral activity. Pramiconazole has a good affinity for 14α-demethylase. Pramiconazole can be used in the study of fungal infections in the local skin, hair, nails, oral cavity, and genital mucosa.
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Fenhexamid (Standard)
0 ImagesSynonyms: KBR 2738 (Standard)Fenhexamid (Standard) is the analytical standard of Fenhexamid. This product is intended for research and analytical applications. Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).
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Antifungal agent 150
0 ImagesCat. No.: HY-W281071CAS No.: 67365-93-9Antifungal agent 150 is an antifungal agent with activity against phytopathogenic fungi and in planta lesion suppression. Antifungal agent 150 inhibits ergosterol biosynthesis via targeted enzyme interaction. Antifungal agent 150 can be used for the research of plant diseases caused by Rhizoctonia solani, including banded leaf and sheath blight of maize.
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1-Dodecylimidazole (Standard)
0 ImagesCat. No.: HY-138540RCAS No.: 4303-67-7Synonyms: N-Dodecylimidazole (Standard)1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
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SDH-IN-30
0 ImagesCat. No.: HY-178050SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research.
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Mps1-IN-9
0 ImagesCat. No.: HY-168155Mps1-IN-9 (compound M-12) is an Mps1-targeted inhibitor discovered for broad-spectrum antifungal agents..
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MFB-1041
0 ImagesCat. No.: HY-125694CAS No.: 151856-47-2MFB-1041 is an orally active antifungal agent, but exhibits poor oral absorption. MFB-1041 induces the binding of drug to serum albumin.
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Concanamycin F
0 ImagesCat. No.: HY-N14426CAS No.: 144539-92-4Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
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Curvulol
0 ImagesCat. No.: HY-N15595CAS No.: 15817-76-2Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL.
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Laccase-IN-6
0 ImagesCat. No.: HY-178189CAS No.: 23750-08-5Laccase-IN-6 is a laccase inhibitor with an IC50 of 0.097 nM. Laccase-IN-6 exhibits broad-spectrum anti-fungal effect and can destroy the normal morphology of the fungi. Laccase-IN-6 can be used for the research of infection.
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Dihydrobiochanin A
0 ImagesCat. No.: HY-169812CAS No.: 83920-62-1Dihydrobiochanin A has antifungal activity. Dihydrobiochanin A is a flavonoid that can isolated from Swartzia polyphylla.
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Laccase-IN-5
0 ImagesCat. No.: HY-170378Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L.
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SM-4470
0 ImagesCat. No.: HY-129585CAS No.: 89433-57-8SM-4470 is an orally active antifungal compound. SM-4470 has inhibitory activity against yeast, Aspergillus, and dermatophytes in vitro.
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Mepronil (Standard)
0 ImagesCat. No.: HY-124408RCAS No.: 55814-41-0Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
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Crotocin
0 ImagesCat. No.: HY-N14547CAS No.: 21284-11-7Crotocin has the fungal activity of anti-cryptococcus neoforme, candida albicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood.
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Gymnoascolide A
0 ImagesCat. No.: HY-N15186CAS No.: 865092-05-3Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 µM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings.
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Enactin Ⅴa
0 ImagesCat. No.: HY-N14219CAS No.: 130640-31-2Enactin Va is found in the strain of Streptomyces roseoviridis. Enactin Va has only weak antifungal activity.
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Antifungal agent 141
0 ImagesCat. No.: HY-179704Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.
