2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12772S3
    Hydroxy Itraconazole-d6
    		Inhibitor
    Hydroxy Itraconazole-d6 (R-63373-d6) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
    Hydroxy Itraconazole-d<sub>6</sub>
  • HY-182477
    Siccayne
    		Inhibitor
    Siccayne, found in the marine basidiomycete Halocyphina villosa and deuteromycete Helminthosporium siccans, is an antibiotic. Siccayne interferes with nucleotide incorporation into DNA and RNA, precursor transport enzymatic reactions, and essential macromolecule synthesis. Siccayne inhibits Gram-positive bacteria and some fungi. Siccayne can be used for research on infections caused by bacteria and fungi.
    Siccayne
  • HY-W751400
    Solasodine hydrochloride
    		Inhibitor
    Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine hydrochloride
  • HY-N14251
    Melithiazole K
    		Inhibitor
    Melithiazol K is an antibiotic. Melithiazole K is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity.
    Melithiazole K
  • HY-N15063
    10-Hydroxyundeca-2,4,6,8-tetraynamide
    		Inhibitor
    10-Hydroxyundeca-2,4,6, 8-tetraynamide is a polyacetylene antibiotic. 10-Hydroxyundeca-2,4,6,8-tetraynamide has anti-Gram-positive bacteria, negative bacteria, yeast, fungus activity and cytotoxicity.
    10-Hydroxyundeca-2,4,6,8-tetraynamide
  • HY-168756
    Byssochlamic acid
    Byssochlamic acid is a secondary metabolite produced by fungal metabolism.
    Byssochlamic acid
  • HY-N15529
    Pipercroside B
    		Inhibitor
    Pipercroside B is found in Piper crocatum Ruiz & Pav. Pipercroside B is a CYP51 inhibitor. Pipercroside B has antifungal activity.
    Pipercroside B
  • HY-B0518AR
    Naftifine hydrochloride (Standard)
    		Inhibitor
    Naftifine (hydrochloride) (Standard) is the analytical standard of Naftifine (hydrochloride). This product is intended for research and analytical applications. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
    Naftifine hydrochloride (Standard)
  • HY-130406
    Benthiavalicarb isopropyl
    Benthiavalicarb isopropyl is a fungicide with specific activity against downy mildew and blight. Benthiavalicarb isopropyl is evaluated for use where necessary to control a serious threat to plant health that cannot be treated by other methods, including non-chemical methods. The use of Benthiavalicarb isopropyl can be considered representative of field applications in potatoes. Environmental and human exposures of Benthiavalicarb isopropyl are considered to be negligible.
    Benthiavalicarb isopropyl
  • HY-Y0248R
    (E,E)-Farnesol (Standard)
    (E,​E)​-​Farnesol (Standard) (trans,trans-Farnesol (Standard)) is the analytical standard of (E,​E)​-​Farnesol (HY-Y0248). This product is intended for research and analytical applications. (E,E)-Farnesol (trans,trans-Farnesol) is a quorum-sensing molecule of Candida species. (E,E)-Farnesol can inhibit the growth, metabolism and biofilm formation of various Candida species, and affect their morphology and invasiveness.
    (E,E)-Farnesol (Standard)
  • HY-169174
    Antifungal agent 116
    		Inhibitor
    Antifungal agent 116 (compund 1a) has broad-spectrum antifungal activity.
    Antifungal agent 116
  • HY-136755
    CYP51-IN-5
    		Inhibitor
    CYP51-IN-5 is a cytochrome P450 14α-demethylase (CYP51) inhibitor and an antifungal (fungal) agent belonging to the triazole derivative class. CYP51-IN-5 is applicable to the research of Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei and Microsporum gypseum.
    CYP51-IN-5
  • HY-N14038
    Crocacin A
    		Inhibitor
    Crocacin A has anti-yeast and filamentous fungal activity. Crocacin A can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin A can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin A
  • HY-128467R
    Dehydroacetic acid sodium (Standard)
    		Inhibitor
    Dehydroacetic acid (sodium) (Standard) is the analytical standard of Dehydroacetic acid (sodium). This product is intended for research and analytical applications. Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
    Dehydroacetic acid sodium (Standard)
  • HY-179411
    Antifungal agent 139
    		Inhibitor
    Antifungal agent 139 (Compound li) is an antifungal agent that exhibits antifungal activity against Colletotrichum gloeosporioides by inhibiting CgSfu1 and CgRidA. Antifungal agent 139 completely inhibits mycelial growth, spore germination, and appressorium formation, with an EC50 of 18 μg/mL. Antifungal agent 139 can completely block the pathogen's infection of host plants (such as linden trees, cypress trees). Antifungal agent 139 can be used for research on anthrax.
    Antifungal agent 139
  • HY-W715370
    Pyrametostrobin
    		Inhibitor
    Pyrametostrobin is a strobilurin fungicide used to protect crops from fungal infection. Pyrametostrobin can be applied to research related to cucumber powdery mildew, powdery mildew, rust, downy mildew and blight.
    Pyrametostrobin
  • HY-N19907
    Phomopsinone A
    		Inhibitor
    Phomopsinone A is an Antifungal agent. Phomopsinone A is isolated from Phomopsis sp. Phomopsinone A exhibits activity against plant and crop pathogens Pyricularia oryzae, Septoria tritici and Botrytis cinerea. Phomopsinone A can be used in the research of plant/crop fungal diseases.
    Phomopsinone A
  • HY-N14923
    Nikkomycin Lz
    		Inhibitor
    Nikkomycin Lz is a nucleoside peptide antifungal compound isolated from genetically engineered Streptomyces tendae TU901. Nikkomycin Lz has antifungal activity against Candida albicans.
    Nikkomycin Lz
  • HY-W094881
    1,5-Dimethylnaphthalene
    1,5-Dimethylnaphthalene is a volatile organic compound. 1,5-Dimethylnaphthalene is a good marker for B. cinerea quantification. 1,5-dimethylnaphthalene is highly positively correlated to B. cinerea infection levels in Chardonnay berries.
    1,5-Dimethylnaphthalene
  • HY-W741041
    Fluoxastrobin-d4
    		Inhibitor
    Fluoxastrobin-d4 is the deuterium labeled Fluoxastrobin. Fluoxastrobin is a fungicide agent.
    Fluoxastrobin-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity