2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1970R
    5,7-Dihydroxychromone (Standard)
    		Inhibitor
    5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection.
    5,7-Dihydroxychromone (Standard)
  • HY-N14936
    AK-toxin Ⅰ
    		Inhibitor
    AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees.
    AK-toxin Ⅰ
  • HY-W017611
    4-Propylphenol
    		Inhibitor
    4-Propylphenol is a plant-derived phenolic compound. 4-Propylphenol causes an increase in ROS within the Fusarium graminearum cells, leading to damage to the DNA and cell membranes of the mycelia, effectively inhibiting the growth of the mycelia. 4-Propylphenol also has a growth inhibitory effect on walnut pathogenic fungi (C. gloeosporioides, C. siamense, A. alternata), with its EC50 ranging from 29.11 to 31.89 mg/L, and it also inhibits spore germination, with EC50 being 55.04-71.85 mg/L. 4-Propylphenol can be used in the research of fungal diseases in walnuts and wheat Fusarium head blight.
    4-Propylphenol
  • HY-N2584AR
    Isoxanthohumol (Standard)
    		Inhibitor
    Isoxanthohumol (Standard) is the analytical standard of Isoxanthohumol (HY-N2584A). This product is intended for research and analytical applications. Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases.
    Isoxanthohumol (Standard)
  • HY-129331
    Neothramycin A
    		Inhibitor
    Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models.
    Neothramycin A
  • HY-137084
    Antibiotic AB023a
    		Inhibitor
    Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum.
    Antibiotic AB023a
  • HY-N12681
    Phoslactomycin A
    		Inhibitor
    Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin A
  • HY-N14157
    Epelmycin C
    		Inhibitor
    Epelmycin C has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin C
  • HY-N14829
    Naphthoquinomycin A
    		Inhibitor
    Naphthoquinomycin A is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids.
    Naphthoquinomycin A
  • HY-117869
    AFK-108
    AFK-108 is a potent antifungal agent. AFK-108 inhibits the activity of 14 alpha-demethylase.
    AFK-108
  • HY-167834
    Farinomalein A
    		Inhibitor
    Farinomalein A is a maleimide that can be isolated from Paecilomyces farinosus. Farinomalein A has potent inhibition of Phytophtora sojae.
    Farinomalein A
  • HY-121109
    Benalaxyl
    		Inhibitor 99.86%
    Benalaxyl is a systemic fungicide. Benalaxyl exhibits inhibitory activity against downy mildew (Peronospora tabacina) in tobacco plants. Benalaxyl can be used in studies related to downy mildew.
    Benalaxyl
  • HY-120729
    Pyrazophos
    		Inhibitor
    Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp..
    Pyrazophos
  • HY-W069116
    Antifungal agent 146
    		Inhibitor 99.55%
    Antifungal agent 146 (Compound 19l) is a broad-spectrum antifungal agent. Antifungal agent 146 has inhibitory effects on the main dermatophytes that cause onychomycosis (Trichophyton rubrum, Trichophyton mentagrophytes) and other fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus) with MIC values of 16, 16, 64, 32, and 32 μg/mL. Antifungal agent 146 can be used for the research of infection.
    Antifungal agent 146
  • HY-180483
    Antifungal agent 144
    		Inhibitor
    Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and 1,3-β-glucan synthase. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger infections.
    Antifungal agent 144
  • HY-W009335R
    Iodopropynyl butylcarbamate (Standard)
    Iodopropynyl butylcarbamate (Standard) is the analytical standard of Iodopropynyl butylcarbamate (HY-W009335). This product is intended for research and analytical applications. odopropynyl butylcarbamate (IPBC) is a potent fungicide and preservative, which has been used in the paints, coatings, wood preservatives, personal care, and cosmetics industries.
    Iodopropynyl butylcarbamate (Standard)
  • HY-129060R
    Flutrimazole (Standard)
    Flutrimazole (Standard) is the analytical standard of Flutrimazole. This product is intended for research and analytical applications. Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
    Flutrimazole (Standard)
  • HY-131044
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
    		Inhibitor
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL.
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
  • HY-N14171
    Epicorazine A
    		Inhibitor
    Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candida albicans with a MIC of 25 μg/mL.
    Epicorazine A
  • HY-N1677R
    2,6-Dimethoxy-1,4-benzoquinone (Standard)
    		Inhibitor
    2,6-Dimethoxy-1,4-benzoquinone (Standard) is the analytical standard of 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677). This product is intended for research and analytical applications. 2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness.
    2,6-Dimethoxy-1,4-benzoquinone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity