GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (782)
Related Products (782)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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Deschloro-Zopiclone
0 ImagesCat. No.: HY-Z1085CAS No.: 1348046-61-6Deschloro-Zopiclone is an impurity of Zopiclone. Zopiclone is the first non-benzodiazepine compound, which can enhance the activity of inhibitory neurotransmitter gamma amino butyric acid in the brain.
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3-Aminopropylphosphinic acid
0 ImagesCat. No.: HY-115763CAS No.: 103680-47-3Synonyms: 3-APPA; CGP 27492; CGA 1478233-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABAB receptor agonist.
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Bentazepam hydrochloride
0 ImagesCat. No.: HY-107323ACAS No.: 29462-19-9Synonyms: QM 6008 hydrochloride; Thiadipone hydrochloride; Tiadipone hydrochlorideBentazepam (QM 6008, Thiadipone) hydrocholide is a compound with short-action anxiolytic effect. Bentazepam hydrocholide shows anticonvulsant and sedative properties. Bentazepam hydrocholide can be used for the research of depressive disorder and anxiety.
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Apronal (Standard)
0 ImagesSynonyms: Allylisopropylacetylurea (Standard); Apronalide (Standard)Apronal (Standard) is the analytical standard of Apronal. This product is intended for research and analytical applications. Apronal (Allylisopropylacetylurea, Apronalide) can bu used for the research of neuropsychiatry disorders.
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P-Hydroxybenzaldehyde-13C6
0 ImagesCat. No.: HY-W747264CAS No.: 201595-48-4P-Hydroxybenzaldehyde-13C6 is the 13C-labeled p-Hydroxybenzaldehyde (HY-Y0313). p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
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U-89843A hydrochloride
0 ImagesCat. No.: HY-103497CAS No.: 157013-85-9Synonyms: PNU-89843 hydrochlorideU-89843A (PNU-89843) hydrochloride is a GABAA receptors positive allosteric modulator (PAM). U-89843A hydrochloride enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. U-89843A hydrochloride shows antioxidant and sedative effects.
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3-Ethyl-3-methylthiolan-2-one
0 ImagesCat. No.: HY-160189CAS No.: 103620-92-43-Ethyl-3-methylthiolan-2-one is an antiepileptic agent that inhibits GABAA receptors.
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HDZI 2,4OH
0 ImagesCat. No.: HY-178482CAS No.: 263153-49-7HDZI 2,4OH exerts significant anti anxiety activity through GABA receptors. HDZI 2,4OH can penetrate the blood-brain barrier. HDZI 2,4OH exhibits low toxicity in zebrafish. HDZI 2,4OH can be used for research on neurological disorders such as anxiety disorders.
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L-663581
0 ImagesCat. No.: HY-118259CAS No.: 122384-14-9Synonyms: FG-8205L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor.
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MmTx2 toxin
0 ImagesCat. No.: HY-P5857Synonyms: Micrurotoxin 2MmTx2 toxin is a GABAA receptor modulator that enhances GABAA receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain.
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CSP-2503
0 ImagesCat. No.: HY-180372CAS No.: 581813-10-7CSP-2503 is a potent and selective 5-HT1A receptor agonist , with an EC50 of 0.15 μM and a Ki of 4.1 nM. CSP-2503 exhibits excellent selectivity over α1-adrenoceptors (Ki > 1000 nM), 5-HT4 receptors, and benzodiazepine receptors. CSP-2503 inhibits cAMP increase in vitro and exhibits anxiolytic activity in vivo. CSP-2503 can be used for the research of anxiety-related disorders.
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GABA-A Receptor Ligand-1
0 ImagesCat. No.: HY-170498CAS No.: 3076335-23-1GABA-A Receptor Ligand-1 (Compound 4) is a ligand for GABA-A receptor with a pKi of 7.27. GABA-A Receptor Ligand-1 reduces mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration. GABA-A Receptor Ligand-1 exhibits neuroprotective efficacy in rats ischemic stroke models.
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GABA-AT-IN-2
0 ImagesCat. No.: HY-180087CAS No.: 898468-56-9GABA-AT-IN-2 (compound 11g) is a GABA aminotransferase (GABA-AT) inhibitor with an IC50 of 19.8 μM. GABA-AT-IN-2 demonstrates notable antianxiety effects in mice. GABA-AT-IN-2 can be used for anxiety-related neurotic disorders research.
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LU-32-176B
0 ImagesCat. No.: HY-118207CAS No.: 770688-66-9LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively.
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CGS-17867A hydrochloride
0 ImagesCat. No.: HY-105481CAS No.: 102200-24-8CGS-17867A hydrochloride is a benzodiazepine receptor ligand. CGS-17867A hydrochloride has a weak sedative effect and can increase palatable food intake.
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Octadecaneuropeptide
0 ImagesCat. No.: HY-P11382CAS No.: 95237-86-8Octadecaneuropeptide is an 18-residue peptide. Octadecaneuropeptide can be derived from Diazepam binding inhibitor. Octadecaneuropeptide includes a specific ligand for the gamma-aminobutyric acid receptor regulatory site occupied by beta-carbolines. Octadecaneuropeptide elicits a dose-related facilitation of the punishment- elicited suppression of drinking.
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Ro 14-7437
0 ImagesCat. No.: HY-116859CAS No.: 78756-03-3Ro 14-7437 is a potent and selective potentiating antagonist of Midazolam.
