Gidazepam
Based on 1 Customer Validation
Gidazepam is an agonist of GABA receptor channels (GABA RCs).
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 129186-29-4
- Formula: C17H15BrN4O2
- Molecular Weight:387.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GABA receptor[1]
Gidazepam demonstrates considerably lower affinities to GABA RCs than phenazepam, 3-hydrozyphenazepam, and Br-nordiazepam. This is manifested in different values of the inhibition constant (Ki) of binding of a specific ligand of benzodiazepine receptors, diazepam. For Gidazepam, the Ki value is 2,200±50 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129186-29-4
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Appearance Solid
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Molecular Weight 387.23
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Formula C17H15BrN4O2
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Color White to off-white
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SMILES
O=C(NN)CN1C(CN=C(C2=CC=CC=C2)C3=CC(Br)=CC=C31)=O
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Synonyms
Gidasepam; Hidazepam; Hydazepam
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (645.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice[1]
The outbreed male white mice (18-22 g) are used. Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam 1 mg/kg (GDZ); GABA ester of menthol 175 mg/kg (1); GABA ester of thymol 20 mg/kg (2); GABA ester of carvacrol 200 mg/kg (3); GABA ester of guaiacol 200 mg/kg (4); mixture of Gidazepam and 1; mixture of Gidazepam and 2; mixture of Gidazepam and 3; mixture of Gidazepam and 4. Doses of esters 1-4 are calculated in equimolar amounts with respect to monoterpenes based on our preliminary investigation and from literature citations. The anticonvulsant activity of compounds 1-4 and Gidazepam as well as mixtures of Gidazepam with 1-4 is evaluated in model of acute generalized seizures; pharmacological effect of compounds is estimated in 3 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5824 mL | 12.9122 mL | 25.8244 mL | 64.5611 mL |
| 5 mM | 0.5165 mL | 2.5824 mL | 5.1649 mL | 12.9122 mL | |
| 10 mM | 0.2582 mL | 1.2912 mL | 2.5824 mL | 6.4561 mL | |
| 15 mM | 0.1722 mL | 0.8608 mL | 1.7216 mL | 4.3041 mL | |
| 20 mM | 0.1291 mL | 0.6456 mL | 1.2912 mL | 3.2281 mL | |
| 25 mM | 0.1033 mL | 0.5165 mL | 1.0330 mL | 2.5824 mL | |
| 30 mM | 0.0861 mL | 0.4304 mL | 0.8608 mL | 2.1520 mL | |
| 40 mM | 0.0646 mL | 0.3228 mL | 0.6456 mL | 1.6140 mL | |
| 50 mM | 0.0516 mL | 0.2582 mL | 0.5165 mL | 1.2912 mL | |
| 60 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0760 mL | |
| 80 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8070 mL | |
| 100 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6456 mL |
Gidazepam Related Classifications
HY-U00315 Related Classifications
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