HIV Protease
HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).
HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.
All Product Categories
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HIV Protease Related Products (203)
Related Products (203)
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Cytochalasin A (Standard)
0 ImagesCat. No.: HY-N6773RCAS No.: 14110-64-6Ketoprofen (lysinate) (Standard) is the analytical standard of Ketoprofen (lysinate). This product is intended for research and analytical applications. Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
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HIV-IN petide
0 ImagesCat. No.: HY-P4543CAS No.: 167875-35-6
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Droxinavir
0 ImagesCat. No.: HY-125494ACAS No.: 159910-86-8Synonyms: SC-55389A free baseDroxinavir (SC-55389A free base) is an HIV-1 protease inhibitor. Droxinavir binds to the S2 and S2' subsites of HIV-1 protease, and this interaction is regulated by protease amino acid residue 88, where the N88S mutation confers viral resistance. Droxinavir can be used in studies related to human immunodeficiency virus type 1 infection.
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Hinnuliquinone
0 ImagesCat. No.: HY-116700CAS No.: 78860-37-4
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JG-365
0 ImagesCat. No.: HY-130366CAS No.: 132748-20-0
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P-1946
0 ImagesCat. No.: HY-182316CAS No.: 449806-40-0P-1946 is a HIV protease inhibitor with a human HIV-1 protease Ki of 2.600 nM. P-1946 has potent and selective in vitro antiviral activity and retains full antiviral activity against HIV isolates resistant to commercially available protease inhibitors. P-1946 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.
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Tipranavir (Standard)
0 ImagesCat. No.: HY-15148RCAS No.: 174484-41-4Synonyms: PNU-140690 (Standard)Tipranavir (Standard) is the analytical standard of Tipranavir. This product is intended for research and analytical applications. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CLpro activity.
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HIV-1-IN-88
0 ImagesCat. No.: HY-179220CAS No.: 2459707-59-4HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1Muta and HIV-1I50V with EC50 values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research.
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AG-1284
0 ImagesCat. No.: HY-105492CAS No.: 162054-18-4
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HIV-IN-12
0 ImagesCat. No.: HY-175561HIV-IN-12 (Compound A1) is a dual HIV-1 Vif and reverse transcriptase (RT) inhibitor. HIV-IN-12 is promising for research of HIV infections.
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Saquinavir (Standard)
0 ImagesSynonyms: Ro 31-8959 (Standard)Saquinavir (Standard) (Ro 31-8959 (Standard)) is the analytical standard of Saquinavir (HY-17007). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
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CGP-75355
0 ImagesCat. No.: HY-117559CAS No.: 191594-64-6CGP-75355 is an inhibitor of HIV-1 protease with IC50 of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.
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KNI-174
0 ImagesCat. No.: HY-187630CAS No.: 141804-42-4
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CGP 57813
0 ImagesCat. No.: HY-129563CAS No.: 150608-41-6CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body.
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A 74704
0 ImagesCat. No.: HY-125571CAS No.: 129467-45-4A 74704 is a pseudo C2-symmetric inhibitor of HIV-1 protease and its diester analog.
