HIV Protease
HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).
HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.
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HIV Protease Related Products (203)
Related Products (203)
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HIV-1 Protease
0 ImagesCat. No.: HY-E70626HIV-1 Protease is synthesized as part of a large Gag-Pol precursor protein. HIV-1 Protease is responsible for its own release from the precursor and the processing of the Gag and Gag-Pol polyproteins into the mature structural and functional proteins required for virus maturation.
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Amprenavir-d4-1
0 ImagesCat. No.: HY-17430S1CAS No.: 2738376-78-6Synonyms: VX-478-d4-1
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Elunonavir
0 ImagesCat. No.: HY-159638CAS No.: 2242428-57-3Elunonavir (GS-1156) is a HIV protease inhibitor with a high barrier to resistance and excellent metabolic stability. Elunonavir is able to overcome rapid CYP-mediated metabolism, resulting in a significantly prolonged half-life and the potential to reduce dosing frequency without the need for pharmacokinetic enhancers.
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HIV-1 inhibitor-53
0 ImagesCat. No.: HY-152200CAS No.: 2883496-10-2HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC50 values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS).
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Ganoderic acid GS-1
0 ImagesCat. No.: HY-N10934CAS No.: 1206781-64-7Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC50 of 58 μM.
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Darunavir Ethanolate (Standard)
0 ImagesSynonyms: TMC114 Ethanolate (Standard)Darunavir (Ethanolate) (Standard) is the analytical standard of Darunavir (Ethanolate). This product is intended for research and analytical applications. Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a Ki of 1 nM for wild type HIV-1 protease.
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Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
0 ImagesCat. No.: HY-P4019CAS No.: 121822-32-0
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Mer-NF5003E
0 ImagesCat. No.: HY-N16422CAS No.: 159121-98-9Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC50=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections.
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HIV-1 protease-IN-8
0 ImagesCat. No.: HY-149936CAS No.: 2925287-55-2HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 μM and 1.90 μM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant.
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Nelfinavir-d4
0 ImagesCat. No.: HY-15287S1Nelfinavir-d4 is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.
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Atazanavir sulfate (Standard)
0 ImagesSynonyms: BMS-232632 sulfate (Standard)Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.
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5-Hydroxynoracronycine
0 ImagesCat. No.: HY-N16745CAS No.: 27067-70-55-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC50 of 93.1 μmol/L against HIV-1 protease and an IC50 of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases.
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Indinavir sulfate ethanolate
0 ImagesCat. No.: HY-B0689BCAS No.: 2563866-80-6Synonyms: MK-639 ethanolate; L735524 ethanolateIndinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibitor.
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Mozenavir
0 ImagesCat. No.: HY-105148CAS No.: 174391-92-5Synonyms: DMP-450Mozenavir (DMP-450) is an orally active cyclic urea HIV-1 protease inhibitor with an IC50 of 76 nM. Mozenavir inhibits replication by targeting viral protease, blocks viral polyprotein processing, and induces the production of core-uncondensed, immature, non-infectious viral particles in chronically infected cells. Mozenavir is applicable to research related to HIV infection.
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Longipedunin A
0 ImagesCat. No.: HY-N12716CAS No.: 886441-72-1Longipedunin A is a HIV-1 Protease inhibitor with an IC50 value of 50 µg/mL.
