2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. U-75875

U-75875 is a HIV-1 protease inhibitor. U-75875 can block Gag-Pol protein processing and viral maturation and replication. U-75875 can be used for the research of infection.

For research use only. We do not sell to patients.

U-75875

U-75875 Chemical Structure

CAS No. : 112190-24-6

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U-75875 Related Antibodies

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Description

U-75875 is a HIV-1 protease inhibitor. U-75875 can block Gag-Pol protein processing and viral maturation and replication. U-75875 can be used for the research of infection[1][2].

Cellular Effect
Cell Line Type Value Description References
CV-1 IC50
0.2 μM
Compound: U-75875
Antiviral efficacy measured by a hybrid HIV-l/vaccinia virus infected monkey cell line (HIV- l/vVK-1 infected CV- 1) which produces HIV-1 gag-pol derived polyproteins
Antiviral efficacy measured by a hybrid HIV-l/vaccinia virus infected monkey cell line (HIV- l/vVK-1 infected CV- 1) which produces HIV-1 gag-pol derived polyproteins
10.1016/S0960-894X(00)80673-3
In Vitro

U-75875 shows an IC50 of 100 μM to SIV-infected PBMC cultures[1].
U-75875 (0.1 μM, 2 h) reduces HIV-1 p24 Ag levels in human fetal brain cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

U-75875 Related Antibodies
In Vivo

U-75875 (7-20 mg/kg, i.v., daily for 26 days) decreases virus load in Rhesus monkeys infected with SIV Delta B670[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rhesus monkeys infected with SIV Delta B670[1]
Dosage: 7 and 20 mg/kg
Administration: Intravenously injection, daily for 26 days
Result: Decreased the level of proviral DNA in peripheral blood mononuclear cells.
Decreased titer of infectious virus.
Molecular Weight

812.01

Formula

C45H61N7O7
CAS No.
SMILES

O=C(NCC1=CC=CC=N1)[C@H]([C@@H](C)CC)NC([C@H](C(C)C)[C@@H](O)[C@H](O)[C@H](CC2CCCCC2)NC([C@H](CC3=CN=CN3)NC(COC4=CC=CC5=C4C=CC=C5)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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U-75875 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-75875112190-24-6U75875U 75875HIV ProteaseHIV-1SIVinfectionInhibitorinhibitorinhibit

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