MMP
Matrix metalloproteinases
MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.
MMP Isoform Specific Products
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MMP-1
(62)
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MMP-2
(134)
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MMP-3
(55)
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MMP-8
(30)
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MMP-9
(174)
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MMP-13
(54)
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MMP-14
(23)
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MMP-17
(3)
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ADAM10
(9)
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ADAM17
(10)
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MMP-7
(20)
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MMP-12
(18)
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MMP-10
(8)
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MMP
(434)
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ADAM8
(1)
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MMP-19
(1)
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All Product Categories
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MMP Inhibitors
(576)
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MMP Agonists
(2)
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MMP Antagonist
(1)
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MMP Activators
(28)
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MMP Modulators
(3)
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MMP Chemicals
(2)
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MMP Inducers
(13)
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MMP Degrader
(1)
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MMP Controls
(5)
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MMP Substrates
(14)
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MMP Ligands
(2)
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Matrix Metalloproteinases Proteins
(43)
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MMP-1 Proteins
(2)
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MMP-2 Proteins
(7)
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MMP-3 Proteins
(2)
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MMP-7 Proteins
(2)
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MMP-10 Proteins
(2)
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MMP-12 Proteins
(3)
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MMP-8 Proteins
(7)
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MMP-9 Proteins
(11)
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MMP-13 Proteins
(1)
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MMP-14 Proteins
(1)
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ADAM8 Proteins
(4)
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ADAM10 Proteins
(1)
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ADAM17/TACE Proteins
(3)
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MMP Related Products (765)
Related Products (765)
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Recombinant Proteins (51)
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Antibodies (15)
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MMP Isoform Comparison
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Levamlodipine besylate Hemipentahydrate
0 ImagesCat. No.: HY-14744DCAS No.: 884648-62-8Levamlodipine besylate Hemipentahydrate is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine besylate Hemipentahydrate significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine besylate Hemipentahydrate not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine besylate Hemipentahydrate exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine besylate Hemipentahydrate may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine besylate Hemipentahydrate can be used in research related to hypertension and atherosclerosis.
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Apratastat (Standard)
0 ImagesCat. No.: HY-119307RCAS No.: 287405-51-0Synonyms: TMI-005 (Standard)Apratastat (Standard) is the analytical standard of Apratastat. This product is intended for research and analytical applications. Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-α. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC). Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Indinavir-13C4,15N
0 ImagesCat. No.: HY-B0689S1Synonyms: MK-639 free base-13C4,15N; L-735524 free base-13C4,15NIndinavir-13C4,15N (MK-639 (free base)-13C4,15N) is 13C and 15N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor.
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MMP3-IN-4
0 ImagesCat. No.: HY-114065CAS No.: 191326-92-8
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CZh226
0 ImagesCat. No.: HY-111103CAS No.: 2196199-00-3CZh226 is a selective PAK4 inhibitor with an IC50 of 0.0111 μM and a Ki of 0.009 μM. CZh226 functionally inhibits PAK4 activity and reduces the phosphorylation level of downstream signaling molecules. CZh226 inhibits the migration and invasion of tumor cells. CZh226 is applicable to lung cancer-related research.
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Aderbasib (Standard)
0 ImagesCat. No.: HY-10293RCAS No.: 791828-58-5Synonyms: INCB007839 (Standard); INCB7839 (Standard)Aderbasib (Standard) is the analytical standard of Aderbasib (HY-10293). This product is intended for research and analytical applications. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al.
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Talopeptin
0 ImagesCat. No.: HY-121514CAS No.: 84235-60-9Talopeptin is a metal protease inhibitor that can be produced by the streptomyces MK-23.
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o-Phenanthroline monohydrate (Standard)
0 Imageso-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor.
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Tianeptine sodium salt (Standard)
0 ImagesTianeptine sodium salt (Standard) is the analytical standard of Tianeptine sodium salt (HY-90003A). This product is intended for research and analytical applications. Tianeptine sodium salt is an atypical antidepressant. Tianeptine sodium salt is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine sodium salt is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine sodium salt increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine sodium salt exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine sodium salt inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine sodium salt can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
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Tremulacin
0 ImagesCat. No.: HY-N11072CAS No.: 29836-40-6Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB4 and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases.
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Anethole (Standard)
0 ImagesSynonyms: Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer.
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L-Val-P
0 ImagesCat. No.: HY-W795259CAS No.: 66254-56-6L-Val-P is a potent leucine aminopeptidase (LAP) inhibitor with a Ki of 0.15 μM. L-Val-P is promising for research of HIV infection, inflammation, eye lens cataract and cancer.
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Isofraxidin (Standard)
0 ImagesIsofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.
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Hinokiflavone (Standard)
0 ImagesCat. No.: HY-N2360RCAS No.: 19202-36-9Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity.
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Abametapir (Standard)
0 ImagesAbametapir (Standard) is the analytical standard of Abametapir. This product is intended for research and analytical applications. Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse.
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TAPI-2 (Standard)
0 ImagesCat. No.: HY-100211RCAS No.: 187034-31-7Synonyms: TNF Protease Inhibitor 2 (Standard)TAPI-2 (Standard) is the analytical standard of TAPI-2 (HY-100211). This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV.
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4-Epianhydrochlortetracycline hydrochloride
0 ImagesCat. No.: HY-120715CAS No.: 158018-53-24-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases.
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JNJ0966 (Standard)
0 ImagesCat. No.: HY-103482RCAS No.: 315705-75-0
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PNU-248686A
0 ImagesCat. No.: HY-19422CAS No.: 341498-89-3PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.
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Trilinolein (Standard)
0 ImagesCat. No.: HY-128393RCAS No.: 537-40-6Trilinolein (Standard) is the analytical standard of Trilinolein (HY-128393). This product is intended for research and analytical applications. Trilinolein is an orally active triglyceride that inhibits the PI3K/Akt, Ras/MEK/ERK signaling pathways, and MMP-2. Trilinolein can reduce oxidative stress, induce apoptosis, and inhibit cell migration. Trilinolein can be used in the research fields of cardiovascular disease, cerebrovascular disease (such as cerebral ischemia), and non-small cell lung cancer.
