Melanocortin Receptor Inhibitor

ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a K_i and IC₅₀ of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier.

Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC₅₀ of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 can cross blood-brain barrier.

N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species.

Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.

Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity.

Mc4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions.

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED₅₀s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders.

MC1R Human Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cadin-1(14)-ene-7a,11-diol is a sesquiterpene alcohol with melanogenesis inhibitory activity. Cadin-1(14)-ene-7a,11-diol inhibits the melanogenesis in B16 melanoma cells induced with α-MSH (HY-P0252). Cadin-1(14)-ene-7a,11-diol can be used as a potential skin-whitening agent.

MC5R Human Pre-designed siRNA Set A contains three designed siRNAs for MC5R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MC4R Human Pre-designed siRNA Set A contains three designed siRNAs for MC4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc2r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc2r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MC3R Human Pre-designed siRNA Set A contains three designed siRNAs for MC3R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MC1R Rat Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC₅₀ of 60 nM.

IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research.