Neprilysin
Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10
Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.
Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.
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Neprilysin Related Products (70)
Related Products (70)
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Recombinant Proteins (2)
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NEP-In-1
0 ImagesCat. No.: HY-U00294CAS No.: 465527-94-0NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.
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SCH 42495
0 ImagesCat. No.: HY-101682CAS No.: 136511-43-8SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
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SQ28603
0 ImagesCat. No.: HY-U00171CAS No.: 100845-83-8Synonyms: SQ28,603; Squibb 28603SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
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NEP-IN-2
0 ImagesCat. No.: HY-U00336CAS No.: 145775-14-0NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.
