Neprilysin
Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10
Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.
Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.
All Product Categories
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Neprilysin Related Products (70)
Related Products (70)
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Recombinant Proteins (2)
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UK-447841
0 ImagesCat. No.: HY-123150CAS No.: 465528-01-2UK-447841 is a selective NEP inhibitor. UK-447841 can be used in the research of female sexual arousal disorder.
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RB-105
0 ImagesCat. No.: HY-19200CAS No.: 155895-89-9RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension.
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(R)-SCH 42495
0 ImagesCat. No.: HY-101682BCAS No.: 156792-25-5(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
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Phosphoramidon
0 ImagesCat. No.: HY-N2021CAS No.: 36357-77-4Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
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Candoxatrilat
0 ImagesCat. No.: HY-117961CAS No.: 123122-54-3Synonyms: UK 73967Candoxatrilat (UK 73967) is an orally active inhibitor of neutral endopeptidase. By elevating the levels of atrial natriuretic peptides, Candoxatrilat exerts its diuretic and natriuretic effects. Candoxatrilat is utilized in the research of heart failure.
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Sacubitrilat-13C4
0 ImagesCat. No.: HY-W747097Synonyms: Desethyl Sacubitril-13C4; LBQ-657-13C4Sacubitrilat-13C4 (Desethyl Sacubitril-13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
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MDL-100240
0 ImagesCat. No.: HY-118264CAS No.: 142695-08-7MDL-100240 is a dual-acting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitor. MDL-100240 can significantly lower blood pressure, reverse left ventricular hypertrophy, and effectively prevent hypertrophy and dilatation of the aorta and resistance arteries, with an effect comparable to that of ramipril (HY-B0279). In addition, MDL-100240 can also reduce aldosterone levels, but has no significant effect on atrial natriuretic peptide and cGMP. In 3-month-old transgenic rats, MDL-100240 can reduce adrenomedullin concentrations, prevent and reverse severe hypertension and cardiovascular damage, and enhance bradykinin effects.
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Azidothiorphan
0 ImagesCat. No.: HY-165466CAS No.: 83960-29-6Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a Ki value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research.
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Aladotril
0 ImagesCat. No.: HY-114941CAS No.: 173429-64-6Synonyms: BP1137Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction.
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Sacubitrilat (Standard)
0 ImagesSynonyms: Desethyl Sacubitril (Standard); LBQ-657 (Standard)Sacubitrilat (Standard) is the analytical standard of Sacubitrilat. This product is intended for research and analytical applications. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
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Kelatorphan (Standard)
0 ImagesCat. No.: HY-10827RCAS No.: 92175-57-0Kelatorphan (Standard) is the analytical standard of Kelatorphan (HY-10827). This product is intended for research and analytical applications. Kelatorphan is a full inhibitor of enkephalin degrading enzymes.
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CGS25155
0 ImagesCat. No.: HY-105351CAS No.: 150126-87-7CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research.
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Dexecadotril
0 ImagesCat. No.: HY-114635CAS No.: 112573-72-5Synonyms: RetorphanDexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action.
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Sacubitril-d5 hemicalcium
0 ImagesCat. No.: HY-15407AS2Synonyms: AHU-377-d5 hemicalciumSacubitril-d5 (AHU-377-d5) hemicalcium is deuterium-labeled Sacubitril hemicalcium (HY-15407A).
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SCH 42495 racemate
0 ImagesCat. No.: HY-101682ACAS No.: 145841-10-7SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
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SCH-34826
0 ImagesCat. No.: HY-19063CAS No.: 105262-04-2SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits NEP and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases.
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Alatrioprilat
0 ImagesCat. No.: HY-117607CAS No.: 135038-59-4Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases.
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Phenylalanylalanine (Standard)
0 ImagesSynonyms: Phe-ala (Standard)Phenylalanylalanine (Standard) (Phe-ala (Standard)) is the analytical standard of Phenylalanylalanine (HY-W009602). This product is intended for research and analytical applications. Phenylalanylalanine is an enkephalinase inhibitor and belongs to the class of dipeptides. Phenylalanylalanine inhibits dipeptidyl carboxypeptidase-mediated enkephalin degradation by cleaving the Gly3-Phe4 bond, and when co-administered with Leu-enkephalin, it produces analgesic effects with a synergistic enhancement, which can be reversed by Naloxone (HY-17417A). Phenylalanylalanine can be used in pain-related research.
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Racecadotril (Standard)
0 ImagesSynonyms: Acetorphan (Standard)Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
