Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (622)
Related Products (622)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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M119
0 ImagesCat. No.: HY-177218CAS No.: 500533-94-8Synonyms: NSC 119910M119 (NSC 119910) is a Gβγ subunit and PLCβ3 inhibitor with selective activity toward μ-opioid receptor-related pathways. M119 selectively inhibits Gβγ-dependent PLCβ3 activation, reduces inositol phosphate production, and enhances μ-opioid receptor-mediated antinociception. M119 attenuates acute μ-opioid receptor agonist-induced antinociceptive tolerance and physical dependence in mice. M119 can be used for pain-related research.
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[Dmt1]DALDA
![[Dmt1]DALDA](https://file.medchemexpress.com/product_pic/hy-p5131.gif "Click to View [Dmt1]DALDA Product Detail")
0 ImagesCat. No.: HY-P5131CAS No.: 255861-98-4[Dmt1]DALDA is a potent and long-acting analgesic binds to the mu opioid receptor with high affinity and selectivity. [Dmt1]DALDA is a full agonist at hMOR (Kd = 0.199 nM) and hDOR, but only partial agonist against hKOR.
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ADL5859
0 ImagesCat. No.: HY-14356CAS No.: 850305-06-5ADL-5859 is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain.
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Kentsin
0 ImagesCat. No.: HY-123492CAS No.: 56767-30-7Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility.
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(Rac)-Enadoline
0 ImagesCat. No.: HY-105236CAS No.: 107431-28-7Synonyms: (Rac)-CI-977 free base(Rac)-Enadoline ((Rac)-CI-977 free base) is a selective K-opioid receptor agonist that stereoselectively antagonizes clonic seizures induced by slow intravenous injection of N-methyl-DL-aspartate in mice.
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Nalmefene hydrochloride
0 ImagesNalmefene hydrochloride is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene hydrochloride is used for opioid overdose and alcohol dependence.
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Anilopam
0 ImagesCat. No.: HY-105604CAS No.: 53716-46-4Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.
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KOR agonist 2
0 ImagesCat. No.: HY-159088CAS No.: 3050912-29-0KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes.
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AT-121 hydrochloride
0 ImagesCat. No.: HY-112692ACAS No.: 2099681-71-5AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects.
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Piperidylthiambutene
0 ImagesCat. No.: HY-W725190ACAS No.: 54160-31-5Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a Ki of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research.
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Bilaid A
0 ImagesCat. No.: HY-P3043CAS No.: 2393865-97-7Bilaid A is a μ-opioid receptor agonist that can be extracted from Penicillium. The Ki value is 3.1 μM. Bilaid A can be used in pain research.
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MT-7716 free base
0 ImagesCat. No.: HY-107094ACAS No.: 610323-32-5Synonyms: W-212393MT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention.
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Nocistatin
0 ImagesCat. No.: HY-P3839CAS No.: 207392-60-7Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a Gi/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.
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(-)-P7C3-S243
0 ImagesCat. No.: HY-186105ACAS No.: 1597443-57-6(-)-P7C3-S243 is an orally active, blood-brain barrier permeable neuroprotective agent. (-)-P7C3-S243 binds to μ-opioid Receptor and TSPO. (-)-P7C3-S243 inhibits the premature apoptosis death of newborn hippocampal neurons, protects mature nigral dopaminergic neurons, promotes neuronal survival and prevents cognitive impairment. (-)-P7C3-S243 ameliorates depression-like behaviors in rat models. (-)-P7C3-S243 is applicable to research related to Parkinson's disease and Alzheimer's disease.
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Neuropeptide AF (human)
0 ImagesCat. No.: HY-P1246CAS No.: 192387-38-5Synonyms: Neuropeptide AF (93-110), humanNeuropeptide AF (human) is an endogenous antiopioid peptide.
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SalA-VS-08
0 ImagesCat. No.: HY-163917CAS No.: 2439152-14-2SalA-VS-08 is a full agonist of kappa-opioid receptor (KOR) with selectivity and G-protein bias. SalA-VS-08 can be used in the research of analgesia.
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MDAN-21
0 ImagesCat. No.: HY-178235CAS No.: 873573-64-9MDAN-21 is a bivalent opioid ligand that contains both μ-opioid receptor agonists and δ-opioid receptor antagonists. MDAN-21 has a strong analgesic effect and does not produce tolerance in mouse studies. MDAN-21 can effectively inhibit the withdrawal of morphine dependent monkeys and alleviate abnormal pain in the study of rhesus monkeys. MDAN-21 can be used for the study of allodynia.
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RSD-921
0 ImagesCat. No.: HY-106131CAS No.: 114419-77-1Synonyms: PD-123497RSD-921 (PD-123497) is a potent Na+ channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na+ channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research.
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Nociceptin(1-7)
0 ImagesCat. No.: HY-P1319CAS No.: 178249-42-8Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.
