PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Thiol-PEG4-Boc
0 ImagesCat. No.: HY-141328CAS No.: 564476-33-1Synonyms: Thiol-PEG4-t-butyl ester
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Boc-NH-PEG5-azide
0 ImagesCat. No.: HY-140837CAS No.: 911209-07-9Boc-NH-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Benzyl-N-bis(PEG3-acid)
0 ImagesCat. No.: HY-140542CAS No.: 2093154-03-9
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Methyltetrazine-PEG24-amine
0 ImagesCat. No.: HY-141262CAS No.: 2353410-18-9
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DBCO-PEG8-acid
0 ImagesCat. No.: HY-140268CAS No.: 2765066-35-9
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Tos-PEG2-C2-Boc
0 ImagesCat. No.: HY-133069CAS No.: 850090-13-0
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Boc-NH-PEG9-azide
0 ImagesCat. No.: HY-140840CAS No.: 2112731-50-5Boc-NH-PEG9-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Fmoc-PEG3-alcohol
0 ImagesCat. No.: HY-W143484CAS No.: 560088-66-6
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N-Ethyl-N-methylpropionamide-PEG1-Br
0 ImagesCat. No.: HY-134733CAS No.: 1695856-63-3
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Tos-PEG7-OH
0 ImagesCat. No.: HY-117028CAS No.: 1028089-05-5
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Tos-PEG9-Tos
0 ImagesCat. No.: HY-140370CAS No.: 109635-64-5
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Tetrazine-Ph-NHCO-PEG3-alcohol
0 ImagesCat. No.: HY-133460CAS No.: 2741569-92-4Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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N-Desthiobiotin-N-bis(PEG4-NHS ester)
0 ImagesCat. No.: HY-140583CAS No.: 2353409-61-5
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Br-PEG4-methyl acetate
0 ImagesCat. No.: HY-138450CAS No.: 3026669-99-5
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Azido-PEG3-Ala-Boc
0 ImagesCat. No.: HY-140849CAS No.: 2054345-68-3Azido-PEG3-Ala-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Ala-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N3-PEG16-Hydrazide
0 ImagesCat. No.: HY-133320N3-PEG16-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG16-Hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5
0 ImagesCat. No.: HY-141052CAS No.: 2107273-50-5N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Methyl-PEG3-Ald
0 ImagesCat. No.: HY-132092CAS No.: 141981-62-6
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THP-PEG5-OH
0 ImagesCat. No.: HY-126917CAS No.: 146395-14-4
