PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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1-Isothiocyanato-PEG3-azide
0 ImagesCat. No.: HY-140843CAS No.: 1310686-23-71-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1-Isothiocyanato-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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2-(5-Bromopentyl)-1,3-dioxolane
0 ImagesCat. No.: HY-W666697CAS No.: 56741-68-5
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HO-PEG6-CH2COOH
0 ImagesCat. No.: HY-133302CAS No.: 120394-66-3
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Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate
![Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate](https://file.medchemexpress.com/product_pic/hy-w048974.gif "Click to View Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate Product Detail")
0 ImagesCat. No.: HY-W048974CAS No.: 94994-25-9
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cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride
0 ImagesCat. No.: HY-W041877CAS No.: 1212304-86-3
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3-(Hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one
0 ImagesCat. No.: HY-W998336CAS No.: 2475-90-3
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Fmoc-NH-PEG3-C2-NH2
0 ImagesCat. No.: HY-133471CAS No.: 906126-25-8
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2-(4-Aminophenyl)ethanol
0 ImagesCat. No.: HY-W005059CAS No.: 104-10-9
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(S,E)-Cyclooct-2-enol
0 ImagesCat. No.: HY-24592CAS No.: 93301-76-9
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N3-C5-O-C-Boc
0 ImagesCat. No.: HY-161792CAS No.: 2836521-02-7
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Benzyl 5-Bromopentanoate
0 ImagesCat. No.: HY-W674673CAS No.: 60343-28-4
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Benzyl 4-(4-((Tert-butoxycarbonyl)amino)butyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W674500CAS No.: 877664-86-3
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(Rac)-Biotin-PEG3-oxyamine hydrochloride
0 ImagesCat. No.: HY-140938ACAS No.: 2823942-01-2
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m-PEG16-NH2
0 ImagesCat. No.: HY-133288CAS No.: 907577-50-8
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BocNH-PEG2-CH2CH2NHMe
0 ImagesCat. No.: HY-W876255CAS No.: 880359-74-0
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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride
![tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-30754.gif "Click to View tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-30754CAS No.: 929302-18-1
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11-Cyanoundecanoic acid
0 ImagesCat. No.: HY-W354597CAS No.: 5810-18-4
