Cbz-NH-PEG5-CH2COOH

Cat. No.: HY-135919 Purity: 99.22%: Data Sheet
COA

SDS
Handling Instructions
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Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Cbz-NH-PEG5-CH2COOH Chemical Structure

CAS No. : 1449390-66-2

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

429.46

Formula

C₂₀H₃₁NO₉

CAS No.

1449390-66-2

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (58.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3285 mL	11.6425 mL	23.2851 mL
5 mM	0.4657 mL	2.3285 mL	4.6570 mL
10 mM	0.2329 mL	1.1643 mL	2.3285 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.22%

Select Batch:

Data Sheet (266 KB) SDS (394 KB)

COA (239 KB) HNMR (185 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3285 mL	11.6425 mL	23.2851 mL	58.2126 mL
	5 mM	0.4657 mL	2.3285 mL	4.6570 mL	11.6425 mL
	10 mM	0.2329 mL	1.1643 mL	2.3285 mL	5.8213 mL
	15 mM	0.1552 mL	0.7762 mL	1.5523 mL	3.8808 mL
	20 mM	0.1164 mL	0.5821 mL	1.1643 mL	2.9106 mL
	25 mM	0.0931 mL	0.4657 mL	0.9314 mL	2.3285 mL
	30 mM	0.0776 mL	0.3881 mL	0.7762 mL	1.9404 mL
	40 mM	0.0582 mL	0.2911 mL	0.5821 mL	1.4553 mL
	50 mM	0.0466 mL	0.2329 mL	0.4657 mL	1.1643 mL