GDF15 Inhibitor

Ponsegromab is a Growth differentiation factor 15 (GDF15) inhibitor with human, cynomolgus monkey, and mouse target IC₅₀ values of 0.123 nM, 0.053 nM, and 0.102 nM, respectively. Ponsegromab acts as a chemosensitizer, increases intracellular reactive oxygen species, reduces glutathione levels. Ponsegromab can be used for the research of oxaliplatin-resistant colorectal cancer.

N‑acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N‑acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N‑acetyltaurine buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N‑acetyltaurine reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N‑acetyltaurine can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes.

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Rilogrotug (AV-380) is a humanized IgG1 monoclonal antibody targeting GDF15.

Gdf15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gdf15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

GDF15 Human Pre-designed siRNA Set A contains three designed siRNAs for GDF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Visugromab (CTL-002) (Powder) is a GDF-15 neutralizing IgG4 mAb. Visugromab (Powder) has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Gdf15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gdf15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes.