Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.
Topoisomerase Isoform Specific Products
All Product Categories
-
Topoisomerase Inhibitors
(751)
View all products
-
Topoisomerase Agonists
(2)
View all products
-
Topoisomerase Modulator
(1)
View all products
-
Topoisomerase Inducer
(1)
View all products
-
Topoisomerase Degraders
(3)
View all products
-
Topoisomerase Controls
(3)
View all products
-
Topoisomerase Ligands
(2)
View all products
-
Topoisomerase Proteins
(1)
View all products
-
DNA topoisomerase II Proteins
(1)
View all products
-
Topoisomerase Related Products (827)
Related Products (827)
-
Recombinant Proteins (1)
-
Antibodies (4)
-
Topoisomerase Isoform Comparison
-
Exatecan-methylacetamide-OH
0 ImagesCat. No.: HY-156849CAS No.: 2594423-51-3Exatecan-methylacetamide-OH (compound 6) is a Exatecan derivative with anticancer effects. Exatecan-methylacetamide-OH is an ADC cytotoxin that can be used to synthesize Antibody-Drug Conjugates (ADCs) (CN112125915A; compound 6).
-
AQ4
0 ImagesCat. No.: HY-121649CAS No.: 70476-63-0AQ4 is a topoisomerase II inhibitor and DNA intercalator as a chemically stable cytotoxic agent in many human tumor lines.
-
Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan
0 ImagesCat. No.: HY-157407CAS No.: 2699066-62-9Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan is a drug-linker conjugate for ADC (ADC Cytotoxin: Exatecan).
-
20-O-Acetylcamptothecin
0 ImagesSynonyms: O-Acetylcamptothecin20-O-Acetylcamptothecin (O-Acetylcamptothecin) is a derivative of Camptothecin (HY-16560) and an inhibitor of Topoisomerase I.
-
Exatecan-amide-cyclopropanol
0 ImagesExatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC50 values of 0.12 and 0.23 nM, respectively.
-
Topoisomerase II inhibitor 20 TFA
0 ImagesCat. No.: HY-158061ATopoisomerase II inhibitor 20 TFA is a potent topoisomerase II inhibitor with IC50 of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity.
-
Deruxtecan-Eribulin
0 ImagesCat. No.: HY-164836Deruxtecan-Eribulin is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule Exatecan (HY-13631) (DNA topoisomerase I inhibitor) and Eribulin (HY-13442) (Microtubule inhibitor). Deruxtecan-Eribulin can be used for ADC synthesis.
-
Pyrazoloacridine
0 ImagesSynonyms: NSC 366140; PD 115934Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment.
-
TH1338
0 ImagesTH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile.
-
Antitumor agent-203
0 ImagesAntitumor agent-203 (例7) is a derivative of Exatecan (DX-8951) (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs), as the ADC Cytotoxin.
-
Camptothecin-20(S)-O-propionate
0 ImagesSynonyms: Camptothecin-20-O-propionateCamptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.
-
Amrubicin hydrochloride
0 ImagesSynonyms: SM-5887 hydrochlorideAmrubicin (SM-5887) hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.
-
Exatecan analog 36
0 ImagesCat. No.: HY-48878Purity: 98.71%Exatecan analog 36 is a analog of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).
-
Epirubicin hydrochloride (Standard)
0 ImagesSynonyms: 4'-Epidoxorubicin hydrochloride (Standard)Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.
-
BWC0977 formic
0 ImagesBWC0977 formic acts as an inhibitor of bacterial Topoisomerase. BWC0977 formic stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 formic can be used in research related to multidrug-resistant bacterial infections.
-
TAS-103
0 ImagesSynonyms: BMS-247615TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
-
Ciprofloxacin hydrochloride monohydrate (Standard)
0 ImagesSynonyms: Bay-09867 hydrochloride monohydrate (Standard)Ciprofloxacin (hydrochloride monohydrate) (Standard) is the analytical standard of Ciprofloxacin (hydrochloride monohydrate). This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
-
Puxitatug samrotecan drug-linker
0 ImagesSynonyms: AZD8205 drug-linkerPuxitatug samrotecan drug-linker (AZD8205 drug-linker) is a drug-linker conjugate for ADC, which comprises a topoisomerase I inhibitor and a linker. Puxitatug samrotecan drug-linker can be used to synthesis antibody-drug conjugate (ADC), Puxitatug samrotecan (HY-171689).
-
Irinotecan-d10
0 ImagesSynonyms: (+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10free baseIrinotecan-d10 is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.
-
Doxorubicin
0 ImagesCat. No.: HY-15142ACAS No.: 23214-92-8Synonyms: HydroxydaunorubicinDoxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy.
