3027162-72-4
3027162-72-4
Chemical Structure
BWC0977 formic
- CAS No.: 3027162-72-4
- Formula:C23H23FN6O7
- Molecular Weight:514.46
InChIKey: FKGFEJVOLZNGPU-ZOWNYOTGSA-N
SMILES: O=C1N(C)C2=C(CCNC[C@H]3CN(C4=CN=C(OCC(N5)=O)C5=N4)C(O3)=O)C(F)=CC=C2C=C1.OC=O
Biological Activity: BWC0977 formic acts as an inhibitor of bacterial Topoisomerase. BWC0977 formic stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 formic can be used in research related to multidrug-resistant bacterial infections[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BWC0977 formic | 99.61% | BWC0977 formic acts as an inhibitor of bacterial Topoisomerase. BWC0977 formic stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 formic can be used in research related to multidrug-resistant bacterial infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Fernandes GFS, et al. Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules. Chemical Society reviews. 2026 Jul 20;55(14):7853-7932.
- [2]. Hameed S, et al.BWC0977, a Novel Dual Target Topoisomerase Inhibitor: Antimicrobial Potency, Spectrum, and Mechanism of Action[C]. 29th European Congress on Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands P. 2019, 1844.
- [3]. Hameed P S, et al. BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections. Nature communications. 2024 Sep 18;15(1):8202. [Content Brief]
- [4]. Nandishaiah R, et al. Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity. Communications biology. 2025 Nov 25;8(1):1666.
