Antibody-Oligonucleotide Conjugates (AOCs)
Antibody-Oligonucleotide Conjugate (AOC) consists of three parts: antibody, linker and oligonucleotide. AOC combines the tissue-specific targeting of antibody drugs with the target-specific capabilities of small nucleic acids, addressing the limitation of current small nucleic acid drugs that mainly target the liver through LNP and GalNAc delivery systems.
Antibody-Oligonucleotide Conjugates (AOCs) Isoform Specific Products
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Antibody-Oligonucleotide Conjugates (AOCs) Related Products (26)
Related Products (26)
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Antibody-Oligonucleotide Conjugates (AOCs) Isoform Comparison
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Cy3 labled Etedesiran
0 ImagesCat. No.: HY-147262CCy3 labled Etedesiran is a Cy3 labled Etedesiran.
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Bis-Mal-Lysine-PEG4-DBCO
0 ImagesCat. No.: HY-186089CAS No.: 3113277-32-7Bis-Mal-Lysine-PEG4-DBCO (CGBS-13) is a linker for AOC drugs and can be used to synthesize AOC drugs that inhibit DMPK gene expression.
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Basivarsen linker
0 ImagesCat. No.: HY-177454CAS No.: 2763758-01-4Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).
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Unconjugated/naked Zoratolimod (without linker)
0 ImagesCat. No.: HY-177973DUnconjugated/naked Zoratolimod (without SMCC linker) is unconjugated/naked Zoratolimod (HY-177973) (without SMCC linker). Zoratolimod can be used to synthesize antibody oligonucleotide conjugates (AOCs). Mozistobart zoratolimod (HY-177568) is used for cancer immunology research.
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Unconjugated/naked Braxlosiran (without SMCC linker)
0 ImagesCat. No.: HY-177971DUnconjugated/naked Braxlosiran (without SMCC linker) is the nucleic acid component of Braxlosiran (HY-177971), lacking both the amino group and the SMCC linker. It can be used to synthesize the AOC agent Delpacibart braxlosiran (HY-177566).
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Unconjugated/naked Etedesiran (without SMCC linker)
0 ImagesCat. No.: HY-147262DUnconjugated/naked Etedesiran (without SMCC linker) is a small interfering RNA (siRNA) targeting DMPK, and also represents the unconjugated, non-SMCC linker-bound component of delpacibart etedesiran. Unconjugated/naked Etedesiran (without SMCC linker) corrects pathogenic mRNA aberrant splicing by targeting and degrading mutant DMPK mRNA, thereby releasing sequestered MBNL splicing factors. Unconjugated/naked Etedesiran (without SMCC linker) can be used in studies of myotonic dystrophy type 1.
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